Minoxidil Local Anesthetic Drugs 38304-91-5 for Curing Hair Loss and Hypertension

Minoxidil White Raw Powder CAS 38304-91-5 for Curing Hair Loss and Hypertension

What is Minoxidil?

Minoxidil is the only FDA approved and most widely used ingredient for hair regrowth as of today. It was first used as an oral drug to lower blood pressure. It was soon found to stimulate hair growth in those who took it to lower blood pressure. Rigorous clinical studies have confirmed this "side effect" and its FAD approvals for hair regrowth as topical solutions were granted, In the 1988, UpJohn Corporation (now known as Rogaine) came out with a topical formulation of Minoxidil at 2%. In the 1990's, UpJohn's patent expired causing the price to come down due numerous generic forms of Minoxidil hitting the market. Rogaine subsequently came out with a 5% Minoxidil solution. Now some Clinics are offering higher than 5% minoxidil to those who do not have satisfactory results with 5% minoxidil.

Basic Information:

Product Specification
Chemical name: Minoxidil
Alternative Name: U-10858
Formula: C9H15N5O
MW: 209.3
CAS: 38304-91-5
MI: 14: 6203
Purity: ≥98% (HPLC)
Appearance: White solid.
Solubility: Soluble in 100% ethanol (29mg/ml), DMSO (6.5mg/ml) or water (2.2mg/ml).
Use/Stability: Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.

Uses:

Minoxidil solution and foam are used to help hair growth in the treatment of male pattern baldness. It is not used for baldness at the front of the scalp or receding hairline in men. The foam and 2 percent minoxidil solution is also used to help hair growth in women with thinning hair.

Minoxidil belongs to a class of drugs known as vasodilators. It is not known how minoxidil causes hair growth. This medication is not used for sudden/patchy hair loss, unexplained hair loss (e.g., no family history of hair loss), or hair loss after giving birth.

Do not use this product if you are 18 years old or younger.

Minoxidil for pattern hair loss:

Minoxidil was originally marketed in a tablet form for the treatment of high blood pressure. One of the side effects of this treatment was unwanted hair growth. This side effect promoted researchers to produce a topical solution for treating hair loss. In some countries, it is available in other formulations such as foam.

Topical minoxidil is used in the treatment of male pattern hair loss in men, and female pattern hair loss in women. It is occasionally useful for other forms of hair loss (alopecia), including alopecia areata, and after hair replacement surgery or chemotherapy.

Minoxidil is marketed in New Zealand as Rogaine™ Topical Solution (5%) and Headway™ Topical Solution (2% and 5%). The 5% solution is probably more effective but it may result in greater irritation than the 2% solution. It is applied to the affected area of the scalp once or twice daily for a minimum of 6 months. If it is found effective, it may be continued long term.

Mechanism of action:

The mechanism by which minoxidil promotes hair growth is not fully understood. Minoxidil is a potassium channel opener, causing hyperpolarization of cell membranes. Hypothetically, by widening blood vessels and opening potassium channels, it allows more oxygen, blood, and nutrients to the follicles. This may cause follicles in the telogen phase to shed, which are then replaced by thicker hairs in a new anagen phase. Minoxidil is a prodrug that is converted by sulfation via the sulfotransferase enzyme SULT1A1 to its active form, minoxidil sulfate. Several studies demonstrated that the activity of sulfotransferase in hair follicles predict minoxidil response in the treatment of hair loss.

Minoxidil is less effective when there is a large area of hair loss. In addition, its effectiveness has largely been demonstrated in younger men who have experienced hair loss for less than 5 years. Minoxidil use is indicated for central (vertex) hair loss only.Minoxidil is also a vasodilator.Two clinical studies are being conducted in the US for a medical device that may allow patients to determine if they are likely to benefit from minoxidil therapy.
 

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