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Isotretinoin CAS 4759-48-2 Yellow Powder Local Anesthetic Drugs for Treatment of Acne Embolism

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Isotretinoin CAS 4759-48-2 Yellow Powder Local Anesthetic Drugs for Treatment of Acne Embolism

China Isotretinoin CAS 4759-48-2 Yellow Powder Local Anesthetic Drugs for Treatment of Acne Embolism supplier

Large Image :  Isotretinoin CAS 4759-48-2 Yellow Powder Local Anesthetic Drugs for Treatment of Acne Embolism

Product Details:

Place of Origin: China
Brand Name: Senwayer
Certification: GMP,ISO9001,KOSHER
Model Number: 4759-48-2

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: Negotiation
Packaging Details: Discreet disguised package or as required
Delivery Time: 3-5 working days
Payment Terms: T/T, , MoneyGram,,Bitcoin
Supply Ability: Mass stock
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Detailed Product Description
Express: TNT,DHL,Fedex, UPS, EMS, HKEMS, Etc. CAS Number: 4759-48-2
MF: C20H28O2 Appearance: Colorless Liquild
Purity: 99.6 % MW: 300.44
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Local Anesthetic Agents


Injectable Local Anesthetics

Isotretinoin CAS:4759-48-2 Yellow Powder for Treatment of Acne Embolism


Isotretinoin Details:


Name: Isotretinoin
Alias: 13-cis Vitamin A acid
CAS: 4759-48-2
MF: C20H28O2
MW: 300.44
EINECS: 225-296-0
Categories:Antibiotics, Organicacids, APIs, Pharmaceuticals, Retinoids
Character: yellow or orange crystalline powder
Solubility: practically insoluble in water, soluble in methylene chloride, slightly soluble in ethanol (96%);
Stability: air, light, heat-sensitive, solution stability worse
Loss on drying: ≤0.5%
Content: 99.8%MIN
Heavy Metal: ≤20ppm
Cell culture Test: Pass
Uses: For the treatment of severe acne embolism
Storage conditions: room temperature, damp and dark airtight and dry.
Packing:100g/foil bag




Product name Isotretinoin (13-cis Vitamin A acid)
CAS No. 4759-48-2 Packing 100G/25KG
Date of manufacturing 2th, July, 2016 Shelf life 1th, July, 2018
Standard USP34
Appearance Yellow or orange crystalline powder Complies
Identification Complies Complies
Loss on drying Not more than 0.5% 0.05%
Residue on ignition Not more than 0.1% 0.02%
Heavy metals Not more than 0.002% <0.002
Tretinoin Not more than 1.0% 0.1%
Assay 98%~102.0% 99.8%
Conclusion Qualified


Medical uses:


Isotretinoin is used primarily for severe cystic acne and acne that has not responded to other treatments.Many dermatologists also support its use for treatment of lesser degrees of acne that prove resistant to other treatments, or that produce physical or psychological scarring.


It is also somewhat effective for hidradenitis suppurativa and some cases of severe acne rosacea.It can also be used to help treat harlequin ichthyosis, lamellar ichthyosis and is used in xeroderma pigmentosum cases to relieve keratoses. Isotretinoin has been used to treat the extremely rare condition fibrodysplasia ossificans progressiva. It is also used for treatment of neuroblastoma, a form of nerve cancer.


Isotretinoin therapy has furthermore proven effective against genital warts in experimental use, but is rarely used for this indication as there are more effective treatments. Isotretinoin may represent an efficacious and safe alternative systemic form of therapy for RCA of the cervix. In most countries this therapy is currently unapproved and only used if other therapies failed.


Mechanism of Action:


Isotretinoin is the only therapy that impacts on all of the major aetiological factors implicated in acne. It achieves this remarkable efficacy by influencing cell-cycle progression, cellular differentiation, cell survival and apoptosis.1–7 It results in a significant reduction in sebum production, influences comedogenesis, lowers surface and ductal P. acnes and has anti-inflammatory properties. A dose of 0.5–1.0 mg/kg/day dramatically reduces sebum excretion by the order of 90% within 6 weeks. Unlike tretinoin (all-trans retinoic acid), isotretinoin has little or no ability to bind to cellular retinol-binding proteins or retinoic acid nuclear receptors (RARs and RXRs) but may act as a pro-drug that is converted intracellularly to metabolites that are agonists for RAR and RXR nuclear receptors.


Do NOT use isotretinoin if:


you are allergic to any ingredient in isotretinoin or to vitamin A
you are pregnant, may become pregnant, or if you are planning to become pregnant
you are breast-feeding

you do not understand the possible risks of isotretinoin or you are not able to follow all of the instructions in the Medication Guide
you are taking tetracycline antibiotics (eg, doxycycline) or vitamin A-type medicines (eg, etretinate, vitamin A)
Contact your doctor or health care provider right away if any of these apply to you.


How should this medicine be used?

Isotretinoin comes as a capsule to take by mouth. Isotretinoin is usually taken twice a day with meals for 4 to 5 months at a time. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take isotretinoin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsules whole with a full glass of liquid. Do not chew or suck on the capsules.


Your doctor will probably start you on an average dose of isotretinoin and increase or decrease your dose depending on how well you respond to the medication and the side effects you experience. Follow these directions carefully and ask your doctor or pharmacist if you are not sure how much isotretinoin you should take.


It may take several weeks or longer for you to feel the full benefit of isotretinoin. Your acne may get worse during the beginning of your treatment with isotretinoin. This is normal and does not mean that the medication is not working. Your acne may continue to improve even after you finish your treatment with isotretinoin.


Isotretinoin CAS 4759-48-2 Yellow Powder Local Anesthetic Drugs for Treatment of Acne Embolism


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