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|Express:||TNT,DHL,Fedex, UPS, EMS, HKEMS, Etc.||CAS Number:||62-44-2|
|Standard:||In-house Standard||Appearance:||White Powder|
|Purity:||99.6 %||Shelf Life:||2 Years|
Local Anesthetic Agents,
Injectable Local Anesthetics
Phenacetin White Raw Powder CAS: 62-44-2 Pharmaceutical Drug 99% Purity
Phenacetin is a phenylacetamide that was formerly used in ANALGESICS but nephropathy and METHEMOGLOBINEMIA led to its withdrawal from the market.
Phenacetin is a synthetic, white crystalline solid that is slightly soluble in water and benzene, soluble in acetone and very soluble in pyrimidine. It is used in research as the preferred marker for detecting CYP1A2-based inhibition potential in vitro. Human ingestion of phenacetin can result in a bluish discoloration of the skin due to a lack of oxygen in the blood (cyanosis), dizziness and respiratory depression. It is reasonably anticipated to be a human carcinogen.
Chemical name: Phenacetin (N- (4-Ethoxyphenyl) acetamide)
Concentration: 6% (w / w; 0.5 M) in CDCl3
Field: 82 MHz
Nuclear testing: 1H
Melting point: 133-135 °C
Applications: Pharmaceuticals, forensics, bench analysis, productivity
|Quantity||5000KG||StandardBP 68 edition|
|Test Items||Specification||Test Results|
|Description||Should comply with the standard||Pass|
|Identification||Should be positive reaction||Pass|
|P-Phenetidine||Brownish red 4#||Pass|
|4-chloroacetanilide||Should comply with standard||Pass|
|Melting point||134℃ to 137 ℃||134 ℃ to 137 ℃|
|Conclusion||Complies with BP68|
Phenacetin was introduced in 1887 in Elberfeld by German company Bayer, and was used principally as an analgesic; it was one of the first synthetic fever reducers to go on the market. It is also known historically to be one of the first non-opioid analgesics without anti-inflammatory properties.
Mechanism of action:
Phenacetin's analgesic effects are due to its actions on the sensory tracts of the spinal cord. In addition, phenacetin has a depressant action on the heart, where it acts as a negative inotrope. It is an antipyretic, acting on the brain to decrease the temperature set point. It is also used to treat rheumatoid arthritis (subacute type) and intercostal neuralgia.
It is metabolized in the body as paracetamol (acetaminophen), which is also a clinically relevant analgesic.
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