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|Delivery:||Express Courier||Brand Name:||Levitra|
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White Vardenafil Raws 99% Powder, Levitra CAS: 224785-91-5 for Sex Enhancement
Vardenafil, known under the brand name Levitra is a prescription medication for male erectile dysfunction treatment. It belongs to a class of drugs called PDE5 inhibitors. Levitra increases blood flow to the penis, which helps gain and sustain an erection during sex. Levitra's active ingredient works on the chain of reactions within the penis during arousal, when the corpus cavernosa (two large chambers) in the male's penis fills with blood, resulting in an erection.
CAS NO.: 224785-91-5
Molecular Formula: C23H32N6O4S
Appearance: White to almost white crystalline powder, odorless, a little acerbity,
soluble in water, ethanol
Use: It is pharmaceutical raw material, indicated for the treatment of erectile dysfunction.
|Test Items||Specification||Test Results|
|Description||White or almost white crystalline powder||White crystalline powder|
|Loss of drying||≤1.0%||0.5%|
|TLC||Only one spot||Only one spot|
|Conclusion||It complies with the USP 32|
Vardenafil was co-marketed by Bayer Pharmaceuticals, GlaxoSmithKline, and Schering-Plough under the trade name Levitra. As of 2005, the co-promotion rights of GSK on Levitra have been returned to Bayer in many markets outside the U.S. In Italy, Bayer sells vardenafil as Levitra and GSK sells it as Vivanza. Thus, because of European Union trade rules, parallel imports might result in Vivanza sold next to Levitra in the EU.
Vardenafil is an oral drug that is used to treat impotence, the inability to attain or maintain a penile erection. It has a mechanism of action that is similar to sildenafil (Viagra), and tadalafil (Cialis). Penile erection is caused by the engorgement of the penis with blood. This engorgement occurs when the blood vessels delivering blood to the penis increase in size and increase the delivery of blood to the penis. At the same time, the blood vessels carrying blood away from the penis decrease in size and decrease the removal of blood from the penis. Sexual stimulation that leads to the engorgement and erection causes the production and release of nitric oxide in the penis. Nitric oxide then activates the enzyme, guanylate cyclase to produce cyclic guanosine monophosphate (cGMP). The cGMP is primarily responsible for increasing and decreasing the size of the blood vessels carrying blood to and from the penis, respectively. Vardenafil prevents an enzyme called phosphodiesterase-5 (PDE-5) from destroying cGMP so that cGMP persists longer. The longer cGMP persists, the more prolonged the engorgement of the penis. Vardenafil was approved by the FDA in August 2003.
How vardenafil and tadalafil work?
Like sildenafil, vardenafil and tadalafil are selective inhibitors of the phosphodiesterase (PDE) isoenzyme PDE-5, which is predominantly responsible for degrading cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the corpus cavernosum.
During sexual stimulation, nitric oxide is released from cavernous nerves and endothelial cells and activates the enzyme guanylate cyclase, resulting in increased cGMP synthesis. The cGMP triggers relaxation of smooth muscles, allowing increased blood flow into the penis and expansion of sinusoidal spaces; this prevents venous blood outflow and results in erection. The PDE-5 inhibitors can potentiate erections by enhancing and prolonging the smooth musclerelaxant effects of the nitric oxide-cGMP cascade in the corpus cavernosum.1 PDE-5 inhibitors have no effect without sexual stimulation.
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|Product name||CAS number|
|Flibanserin (Female Viagra)||167933-07-5|
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