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Vincristine Sulfate CAS 2068-78-2 White Raw Drug for Anti - Tumor Treatment

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Vincristine Sulfate CAS 2068-78-2 White Raw Drug for Anti - Tumor Treatment

China Vincristine Sulfate CAS 2068-78-2 White Raw Drug for Anti - Tumor Treatment supplier

Large Image :  Vincristine Sulfate CAS 2068-78-2 White Raw Drug for Anti - Tumor Treatment

Product Details:

Place of Origin: China
Brand Name: Senwayer
Certification: GMP,ISO9001,KOSHER
Model Number: 2068-78-2

Payment & Shipping Terms:

Minimum Order Quantity: 1g
Price: Negotiation
Packaging Details: Discreet disguised package or as required
Delivery Time: 3-5 working days
Payment Terms: T/T, , MoneyGram,,Bitcoin
Supply Ability: Mass stock
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Detailed Product Description
Appearance: White Powder CAS Number: 2068-78-2
MF: C46H58N4O14S MW: 923.04
MOQ: 1g Usage: Pharmaceutical Raw Materials
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Vincristine Sulfate CAS: 2068-78-2 White Raw Drug for Anti-Tumor Treatment




Vincristine Sulfate, a dimeric Vinca alkaloid, has been shown to bind to Tubulin via a protein self association reaction. This compound acts as a Tubuiln inhibitor by binding to sites at the ends of microtubules, which regulate the inhibition of Tubulin dimer addition to microtubule ends. Experiments have reported Vincristine Sulfate to demonstrate a capacity to suppress growth of proliferating cells through marked apoptosis and cell cycle arrest at G2/M. The cell death caused by this agent seems to result in a sustained accumulation of endogenous ceramide levels. Ceramide, has been proposed as a lipid second messenger with specific antiproliferative mediating responses. Vincristine Sulfate is an inhibitor of MAO. Vincristine Sulfate is also a substrate of PGP and CYP3A4.


Quick Details:

Formal Name: 22-oxo-vincaleukoblastine sulfate
CAS Number: 2068-78-2
Synonyms: Kyocristine, Lilly 37231, Leurocristine, Novopharm, NSC 67574, Oncovin, VCR
Molecular Formula: C46H56N4O10 • H2SO4
Formula Weight: 923.0
Purity: ≥95%
Formulation: A crystalline solid
λmax: 221, 259, 296 nm
Storage: -20°C




Product name Vincristine Sulfate
CAS No. 2068-78-2 Outer Packing 10g/foil bag
Production date 2015-09-07 Shelf life 2017-09-06
Standard adopted USP35
Items of analysis Specification Results
Appearance White to slightly yellow crystalline powder White powder
Solubility Freely soluble in water Conform
Identification IR Spectrum of the sample corresponds Conform
Reaction of sulfate Positive for sulfate Conform
PH 3.5~4.5 3.9
Loss on drying NMT 12.0% 8.32%
Individual impurity NMT 1.0% 0.76%
Total impurities NMT4.0% 1.8%
Ethanol NMT 0.5% 0.1%
Methanol NMT 0.3% 0.002%
Acetone NMT 0.5% 0.0003%
Chloroform NMT 0.006% 0.0008%
Benzene NMT 0.0002% <0.00001%
Bacterial Endotoxins NMT 500cfu/g <20cfu/g
Mold and Yeast NMT 50cfu/g <20cfu/g
Escherichia coli Not Found/g Not Found/g
Assay(HPLC) 95.0~102.0% 96.7%
Conclusion Qualified


Medical uses:

Vincristine is delivered via intravenous infusion for use in various types of chemotherapy regimens.[3] Its main uses are in non-Hodgkin's lymphoma as part of the chemotherapy regimen CHOP, Hodgkin's lymphoma as part of MOPP, COPP, BEACOPP, or the less popular Stanford V chemotherapy regimen in acute lymphoblastic leukemia (ALL), and in treatment for nephroblastoma.It is also used to induce remission in ALL with dexamethasone and L-Asparaginase, and in combination with prednisone to treat childhood leukemia.Vincristine is occasionally used as an immunosuppressant, for example, in treating thrombotic thrombocytopenic purpura (TTP) or chronic idiopathic thrombocytopenic purpura (ITP).

How Vincristine Works:

Cancerous tumors are characterized by cell division, which is no longer controlled as it is in normal tissue. "Normal" cells stop dividing when they come into contact with like cells, a mechanism known as contact inhibition. Cancerous cells lose this ability. Cancer cells no longer have the normal checks and balances in place that control and limit cell division. The process of cell division, whether normal or cancerous cells, is through the cell cycle. The cell cycle goes from the resting phase, through active growing phases, and then to mitosis (division).

The ability of chemotherapy to kill cancer cells depends on its ability to halt cell division. Usually, the drugs work by damaging the RNA or DNA that tells the cell how to copy itself in division. If the cells are unable to divide, they die. The faster the cells are dividing, the more likely it is that chemotherapy will kill the cells, causing the tumor to shrink. They also induce cell suicide (self-death or apoptosis).

Chemotherapy drugs that affect cells only when they are dividing are called cell-cycle specific. Chemotherapy drugs that affect cells when they are at rest are called cell-cycle non-specific. The scheduling of chemotherapy is set based on the type of cells, rate at which they divide, and the time at which a given drug is likely to be effective. This is why chemotherapy is typically given in cycles.

Chemotherapy is most effective at killing cells that are rapidly dividing. Unfortunately, chemotherapy does not know the difference between the cancerous cells and the normal cells. The "normal" cells will grow back and be healthy but in the meantime, side effects occur. The "normal" cells most commonly affected by chemotherapy are the blood cells, the cells in the mouth, stomach and bowel, and the hair follicles; resulting in low blood counts, mouth sores, nausea, diarrhea, and/or hair loss. Different drugs may affect different parts of the body.



Vincristine Sulfate CAS 2068-78-2 White Raw Drug for Anti - Tumor Treatment


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