Vincristine Sulfate CAS 2068-78-2 White Raw Drug for Anti - Tumor Treatment

Vincristine Sulfate CAS: 2068-78-2 White Raw Drug for Anti-Tumor Treatment

Description:

Vincristine Sulfate, a dimeric Vinca alkaloid, has been shown to bind to Tubulin via a protein self association reaction. This compound acts as a Tubuiln inhibitor by binding to sites at the ends of microtubules, which regulate the inhibition of Tubulin dimer addition to microtubule ends. Experiments have reported Vincristine Sulfate to demonstrate a capacity to suppress growth of proliferating cells through marked apoptosis and cell cycle arrest at G2/M. The cell death caused by this agent seems to result in a sustained accumulation of endogenous ceramide levels. Ceramide, has been proposed as a lipid second messenger with specific antiproliferative mediating responses. Vincristine Sulfate is an inhibitor of MAO. Vincristine Sulfate is also a substrate of PGP and CYP3A4.

Quick Details:
 

Formal Name: 22-oxo-vincaleukoblastine sulfate
CAS Number: 2068-78-2
Synonyms: Kyocristine, Lilly 37231, Leurocristine, Novopharm, NSC 67574, Oncovin, VCR
Molecular Formula: C46H56N4O10 • H2SO4
Formula Weight: 923.0
Purity: ≥95%
Formulation: A crystalline solid
λmax: 221, 259, 296 nm
Storage: -20°C

COA:

Medical uses:

Vincristine is delivered via intravenous infusion for use in various types of chemotherapy regimens.[3] Its main uses are in non-Hodgkin's lymphoma as part of the chemotherapy regimen CHOP, Hodgkin's lymphoma as part of MOPP, COPP, BEACOPP, or the less popular Stanford V chemotherapy regimen in acute lymphoblastic leukemia (ALL), and in treatment for nephroblastoma.It is also used to induce remission in ALL with dexamethasone and L-Asparaginase, and in combination with prednisone to treat childhood leukemia.Vincristine is occasionally used as an immunosuppressant, for example, in treating thrombotic thrombocytopenic purpura (TTP) or chronic idiopathic thrombocytopenic purpura (ITP).

How Vincristine Works:

Cancerous tumors are characterized by cell division, which is no longer controlled as it is in normal tissue. "Normal" cells stop dividing when they come into contact with like cells, a mechanism known as contact inhibition. Cancerous cells lose this ability. Cancer cells no longer have the normal checks and balances in place that control and limit cell division. The process of cell division, whether normal or cancerous cells, is through the cell cycle. The cell cycle goes from the resting phase, through active growing phases, and then to mitosis (division).

The ability of chemotherapy to kill cancer cells depends on its ability to halt cell division. Usually, the drugs work by damaging the RNA or DNA that tells the cell how to copy itself in division. If the cells are unable to divide, they die. The faster the cells are dividing, the more likely it is that chemotherapy will kill the cells, causing the tumor to shrink. They also induce cell suicide (self-death or apoptosis).

Chemotherapy drugs that affect cells only when they are dividing are called cell-cycle specific. Chemotherapy drugs that affect cells when they are at rest are called cell-cycle non-specific. The scheduling of chemotherapy is set based on the type of cells, rate at which they divide, and the time at which a given drug is likely to be effective. This is why chemotherapy is typically given in cycles.

Chemotherapy is most effective at killing cells that are rapidly dividing. Unfortunately, chemotherapy does not know the difference between the cancerous cells and the normal cells. The "normal" cells will grow back and be healthy but in the meantime, side effects occur. The "normal" cells most commonly affected by chemotherapy are the blood cells, the cells in the mouth, stomach and bowel, and the hair follicles; resulting in low blood counts, mouth sores, nausea, diarrhea, and/or hair loss. Different drugs may affect different parts of the body.

 

Our Advantages:

1.Good reputation
Our company is a leading chemical company in China, and has more than 16 years history. We have over 10 branch offices, all enjoy good reputation from worldwide customers.

2.High Quality&low price
All of our products have top quality and high purity, since we are the factory, our price is competitive.

3.Multiple payment methods.
We have mutiple payment methods, T/T, Western Unoin, MoneyGram, and Bitcoin for your convenience.

4.Mass Stock
In order to better serve our customers, we are preparing mass stock in our warehouse, we can always ship your parcel within 24 hours.

5.High customs clearance pass rate.
Through 16 years hard work, we have accumulated rich exporting experience to USA, UK, France, Italy, Germany,Spain, Brail, korea, India and so on.We will use special ways to disguise the goods, 98% customs clearance rate is guaranteed, if the delivery is not successful, we will resend for free.

6.Warm After service.
If you have any problems about the goods, do no hesitate to contact us, we can provide 7/24 service.

 

If you have any question pls feel free to contact me via:

Email: export@senwayer.com
Whats-app:+86-18186442580
Wickr me:yukis8888
We-chat:+86-18186442580
Tele-gram:+86-18186442580