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Product Details:
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CAS: | 6533-00-2 | Appearance: | White Powder |
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MF: | C21H28O2 | MW: | 312.45 |
EINECS: | 212-349-8 | Melting Point: | 239-241 °C(lit.) |
High Light: | Estrogen Blocker Steroids,Pharma Grade Steroids |
Anti-Estrogen Norgestrel CAS 6533-00-2 Purity 99.5% to Prevent Pregnancy
Norgestrel is used to prevent pregnancy. It is often referred to as the "mini-pill" because it does not contain any estrogen. Norgestrel (a form of progestin) is a hormone that prevents pregnancy by changing the womb and cervical mucus to make it more difficult for an egg to meet sperm (fertilization) or for the fertilized egg to attach to the wall of the womb (implantation). Regular use of the "mini-pill" prevents the release of an egg (ovulation) in about half of the women who use it.Norgestrel is usually used by women who cannot take estrogen. For the most effective results, it is very important to take this medication exactly as prescribed.
Quick Details:
Product name:Norgestrel
Synonyms: OVRETTE(R);NORPLANT;NORGESTREL;NORGESTREL(LEVO);17-ALPHA-ETHYNYL-18-HOMO-19-NORTESTOSTERONE;18,19-DINOR-13-BETA-ETHYL-17-BETA-HYDROXY-4-PREGNEN-20-YN-3-ONE;18,19-DINOR-4-PREGNEN-20-YN-3-ONE;13BETA-ETHYL-17ALPHA-ETHYNYL-17BETA-HYDROXYGON-4-EN-3-ONE
CAS:6533-00-2
MF: C21H28O2
MW: 312.45
Purity:99.5% min
EINECS: 212-349-8
Appearance:White powder
MP:239-241 °C(lit.)
Storage temp:2-8°C
Product Categories: Hormone;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Chiral Reagents;Glucuronides;Metabolites & Impurities;SARIDON.
COA:
Product name
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Norgestrel | ||
CAS No.
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6533-00-2 |
Outer Packing
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25KG |
Production date
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2015.01.23 |
Shelf life
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2019.01.22 |
Standard adopted
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USP35 | ||
Items of analysis
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Specification
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Results
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Description | White or Practically white odorless powder | White odorless powder | |
Identification | IR is consistentwith contrastsubstance | Passed | |
Melting Point | Melting range between 205 — 212 ℃ ,the range between beginning and of end melting does notexceed 4℃ | 205.5—207.5℃ | |
Specific Rotation | -0.10°— +0.10° | -0.00° | |
Ethinyl | Should be 7.81—8.18% | 7.917% | |
Other steroid | Sum of impurities points notmore than 5 | Passed | |
Impurity Point | ≤2.0% | 1.1% | |
Amountof impurity | ≤0.5% | 0.08% | |
Loss On Drying | ≤0.3% | 0.12% | |
Residual Solvents | acetone≤0.5% | 0.04% | |
Assay | 98.0—102.0%(on the dried basis) | 99.11 % | |
Conclusion
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Qualified
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Mechanism of Action:
Norgestrel binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like Norgestrel will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone)
Norgestrel, a synthetic progesterone analog , is a racemic mixture of which levonorgestrel is the biologically active component. Levonorgestrel prevents pregnancy by inhibiting ovulation and by causing the cervical mucous to thicken, which makes it harder for sperm to move toward the uterus.
Pharmacology:
Norgestrel is used as a female contraceptive. Norgestrel is a progestin or a synthetic form of the naturally occurring female sex hormone, progesterone. In a woman's normal menstrual cycle, an egg matures and is released from the ovaries (ovulation). The ovary then produces progesterone, preventing the release of further eggs and priming the lining of the womb for a possible pregnancy. If pregnancy occurs, progesterone levels in the body remain high, maintaining the womb lining. If pregnancy does not occur, progesterone levels in the body fall, resulting in a menstrual period. Norgestrel tricks the body processes into thinking that ovulation has already occurred, by maintaining high levels of the synthetic progesterone. This prevents the release of eggs from the ovaries.
Norgestrel Dosage:
You will take your first pill on the first day of your period or on the first Sunday after your period begins. You may need to use back-up birth control, such as condoms or a spermicide, when you first start using this medication. Follow your doctor's instructions.
Take one pill every day, no more than 24 hours apart. When the pills run out, start a new pack the following day. You may get pregnant if you do not take one pill daily. Get your prescription refilled before you run out of pills completely.
The 28 day birth control pack contains seven "reminder" pills to keep you on your regular cycle. Your period will usually begin while you are using these reminder pills.
What if I miss a dose?
Try not to miss a dose. Every time you miss a dose or take a dose late your chance of pregnancy increases. When 1 pill is missed (even if only 3 hours late), take the missed pill as soon as possible and continue taking a pill each day at the regular time (use a back up method of birth control for the next 48 hours). If more than 1 dose is missed, use an additional birth control method for the rest of your pill pack until menses occurs. Contact your health care professional if more than 1 dose has been missed.
If you have any question pls feel free to contact me via:
Email: export@senwayer.com
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Wickr me:yukis8888
We-chat:+86-18186442580
Tele-gram:+86-18186442580