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|Appearance:||White Powder||CAS Number:||2557-49-5|
|MOQ:||1g||Usage:||Pharmaceutical Raw Materials|
Local Anesthetic Agents,
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Anti-Inflammatory Powder Diflorasone CAS: 2557-49-5 Glucocorticoids Steroids
Diflorasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties. Like other glucocorticoids, diflorasone enters the cell by diffusion across the cell membrane and binds to the glucocorticoid receptor (GR) in the cytoplasm. The receptor complex subsequently translocates to the nucleus and activates or represses genes by interacting with short, palindromic DNA sequences called glucocorticoid response element (GRE). Gene activation leads to the exertion of anti-inflammatory effects, e.g. upregulation of IkappaB, while gene repression inhibits production of pro-inflammatory cytokines such as interleukin-1 (IL-1), IL-2 and IL-6, thereby preventing activation of cytotoxic T-lymphocytes.
Chemical Name: DIFLORASONE
Molecular Formula: C22H28F2O5
Formula Weight: 410.45
CAS No.: 2557-49-5
Appearance: White powder
|CAS No.||2557-49-5||Outer Packing||1KG/bag|
|Production date||2014.09.16||Shelf life||2017.09.15|
|Standard adopted||In-house Standard|
|Items of analysis||Specification||Results|
|Description||White to off-white powder||white powder|
|Identification (IR,HPLC)||Complies with the Standard||Complies|
|Loss on drying||Not more than 0.5%||0.08%|
|Sulphated ash||Not more than 0.1%||0.04%|
|Single unknown impurity||Not more than 0.10%||0.1%|
|total impurities||Not more than 1.0%||0.16%|
|Assay(HPLC, basis on drying)||98.0%~102.0%||99.8%|
|Methanol||Not more than 3000ppm||169ppm|
|Acetonitrile||Not more than 410ppm||n.d|
|Isopropenyl acetate||Not more than 5000ppm||n.d|
|Dichloromethane||Not more than 600ppm||87ppm|
|Dimetylformamide||Not more than 880ppm||n.d|
Diflorasone is used to treat a variety of skin conditions (e.g., eczema, dermatitis, allergies, rash). Diflorasone reduces the swelling, itching and redness that can occur in these types of conditions. This medication is a strong (high-potency) corticosteroid.
How to use diflorasone topical
Use this medication only on the skin. However, do not use it on the face, groin or underarms unless directed to do so by your doctor.
Wash and dry your hands before applying. Clean and dry the affected area. Apply a thin film of the medication to the affected area and gently rub in, usually 1-3 times daily or as directed by your doctor. Do not bandage, wrap or cover the area unless directed to do so by your doctor. If used in the diaper area on an infant, do not use tight-fitting diapers or plastic pants...
How should this medicine be used?
Diflorasone comes as a cream and an ointment to apply to the skin. It is usually applied to the affected area one to three times a day. To help you remember to use diflorasone, apply it around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use diflorasone exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.
Wash or soak the affected area thoroughly before applying the medicine, unless it irritates your skin. Then apply the ointment or cream sparingly in a thin film and rub it in gently.
If you are using diflorasone on your face, keep it out of your eyes.
If you are using diflorasone on a child's diaper area, do not use tight-fitting diapers or plastic pants. Such use may increase side effects.
Do not apply cosmetics or other skin preparations on the treated area without talking with your doctor.
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