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|CAS Number:||14484-47-0||Appearance:||White To Light Yellow Powder|
Injectable Local Anesthetics,
Local Anesthetic Powder
Glucocorticoid Pharmacy Powder Deflazacort 14484-47-0 for Anti-Inflammatory
Product name: Deflazacort
English Synonyms: Azacort,Deflan,Deflazacortum,Flantadin,Lantadin,Oxazacort
CAS NO.: 14484-47-0
Molecular Weight: 441.52
Packing: foil bag
Appearance: White or almost white crystalline powder
Usage: Have anti-inflammatory, anti-allergic effects, the equivalent of prednisolone 10 to 20 times the decline for the adrenal cortex function, autoimmune diseases, allergic diseases and blood diseases
|CAS No.||13649-88-2||Outer Packing||1kg|
|Production code||Feb.,11,2015||Shelf life||Feb,10,2017|
|Standard adopted||Enterprise standard|
|Item of analysis||Specification||Results|
|Appearance||white to yellowish powder||complies|
|Identification(A and B)||(A)Infrared Spectrum: (TF) Corresponds to Standard.(B)Raman: the maxima in the spectrum correspond in position and relative intensity to those in the spectrum obtained with the Reference Substance||complies|
|Loss on drying||Not more than 2.0%||0.08%|
|Related substances(HPLC)||Impurity rrt 2.0 ≤ 0.10||n.d|
|Related substances(HPLC)||Total impurities ≤ 2.0%||0.81%|
|Assay (on drying)||Not less than 97.0%||99.2%|
Deflazacort, an investigational drug, is a glucocorticoid with anti-inflammatory and immunosuppressant properties.2 Deflazacort is not currently approved in the United States for any indication. Versions of deflazacort are available in some countries outside the United States where it is approved for a number of indications, but not for Duchenne. If approved, deflazacort will be among the first commercially available treatments indicated for Duchenne in the United States. As of the date of the NDA filing acceptance, there is no cure for Duchenne and currently no FDA-approved treatment.
Deflazacort belongs to a group of medicines called corticosteroids. It is sometimes referred to simply as an oral steroid.
Corticosteroids like deflazacort are used to treat a wide variety of conditions. Some examples include autoimmune diseases (for example, systemic lupus erythematosus (SLE), autoimmune hepatitis, sarcoidosis), joint and muscle diseases (for example, rheumatoid arthritis), and allergies and asthma. They are also used in the treatment of some cancers.
Deflazacort works by interfering with the release of certain chemicals in your body which cause inflammation.
How it works?
Defcort is a corticosteroid drug. It increases the level of glucocorticoid in the body and works by decreasing the formation of substances that cause inflammation and suppresses immunity to stops self damage to body by immune system (auto-immune reactions occurring in organ transplants or cancer).
Weight gain, increased appetite, facial puffiness or Cushingoid appearance, unwanted hair growth, skin redness, and headache.
Other less common but important side effects include: a decrease in the density of the bones (osteopenia) or fragility of the bones (osteoporosis) which may lead to fractures, acne, stomach upset or irritation to the stomach lining, cataracts (which can impair vision), increased susceptibility to infection, sugar intolerance and aggravation of diabetes, elevation in blood pressure, behavioral and mood changes, effects on growth and development such as short stature.
Deflazacort use is not recommended for patients who have a systemic fungal infection or are allergic to deflazacort or any of the inactive ingredients in deflazacort, have had recent or ongoing infections or have recently received a vaccine or are scheduled for a vaccination.
Package and Storage:
1. Paperboard barrel lined with two-layer polyethylene film bag;
2. Tightly sealed in a clean,cool,dry area, keep away from strong, direct light.
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