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|CAS Number:||378-44-9||Appearance:||White Powder|
|Purity:||99.68%||Synonyms:||Bifas; Bebate; Becort|
Local Anesthetic Agents,
Local Anesthetic Powder
Cortico Anti Inflammatory Local Anesthetic Powder Betamethasone 378-44-9
Betamethasone is classed as a potent topical corticosteroid. Topical corticosteroids are also referred to as topical steroids. Topical steroids are used in addition to moisturisers (emollients) for treating inflammatory skin conditions such as eczema and dermatitis. A topical steroid is used when patches of eczema or dermatitis flare up. Betamethasone relieves the symptoms of a flare-up by reducing inflammation, itching and redness. It is not a cure for the condition, but it will help to relieve the symptoms. Short courses of betamethasone may also be prescribed for the treatment of psoriasis for small areas such as the scalp, soles of the feet, or palms of the hands.
Synonyms: Bifas; Bebate; Becort
Molecular formula: C22H29FO5
Quality Standards: CP2005/USP/BP/EP
Chemical Properties: White to Off-White Solid
|Item of Analysis||Specification||Results|
|Appearance||White or almost white crystalline powder||Complies|
|Solubility||Practically insoluble in water||Complies|
|Identification (B,C)||Complies with the Standard||Complies|
|Specific optical Rotation||+118°～+126°||+123.6°|
|Single impurity||Not more than 1.0%||0.36%|
|impurity that ≥0.5%||Not more than one||Complies|
|total impurities||Not more than 2.0%||0.84%|
|Loss on drying||Not more than 1.0%||0.10%|
|Assay(UV, basis on drying)||97.0%～103.0%||99.80%|
|Methanol||Not more than 3000ppm||Complies|
|Ethyl acetate||Not more than 5000ppm||Complies|
|Acetone||Not more than 5000ppm||Complies|
|DMF||Not more than 880ppm||Complies|
|Dichloromethane||Not more than 600ppm||Complies|
|Chloroform||Not more than 60ppm||Complies|
Betamethasone is a corticosteroid that is available as pill, by injection, and as a cream.
It is used as a topical cream to relieve skin irritation, such as itching and flaking from eczema. It is used as a treatment for local psoriasis, as betamethasone dipropionate and salicylic acid, or as the combination calcipotriol/betamethasone dipropionate. Betamethasone sodium phosphate is used orally and via injection with the same indications as other steroids. Many betamethasone-based pharmaceuticals include the steroid as the valerate ester.
In a randomized controlled trial betamethasone was shown to reduce some of the ataxia symptoms associated with ataxia telangiectasia (A-T) by 28-31%.
Betamethasone is also used to stimulate fetal lung maturation (to prevent IRDS), and to decrease the incidence and mortality from intracranial hemorrhage in premature infants.
A cream with 0.05% betamethasone appears effective in treating phimosis in boys,and often averts the need for circumcision.It has replaced circumcision as the preferred treatment method for some physicians in the British National Health Service.
How it Works?
Betamethasone is a corticosteroid drug, sometimes called a steroid. Steroids reduce the amount of inflammatory chemicals your body makes. They also reduce your body’s natural immune response to control inflammation.
How to use betamethasone:
Use betamethasone as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Betamethasone is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using betamethasone at home, a health care provider will teach you how to use it. Be sure you understand how to use betamethasone. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
Do not use betamethasone if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
If you miss a dose of betamethasone, contact your doctor right away.
Ask your health care provider any questions you may have about how to use betamethasone.
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