Inflammatory Release Medical Local Anesthetic Drugs Dexamethasone CAS 50-02-2

Inflammatory Release Medical Local Anesthetic Drugs Dexamethasone CAS 50-02-2

Description:

Dexamethasone is a type of steroid medication.It is used in the treatment of many conditions, including rheumatic problems, a number of skin diseases, severe allergies, asthma, chronic obstructive lung disease, croup, brain swelling, and along with antibiotics in tuberculosis.In adrenocortical insufficiency, it should be used together with a medication that has greater mineralocorticoid effects such as fludrocortisone.In preterm labor, it may be used to improve outcomes in the baby.It may be taken by mouth, as an injection into a muscle, or intravenously.The effects of dexamethasone are frequently seen within a day and last for about three days.

Specifications:

Product Name: Dexamethasone
Synonyms: 16alpha)-;16alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-(11bet;16alpha-methyl-9alpha-fluoro-1,4-pregnadiene-11beta,17alpha,21-triol-2,20-dione;16-alpha-methyl-9-alpha-fluoro-1,4-pregnadiene-11-beta,17-alpha,21-triol-3,2;16-alpha-Methyl-9-alpha-fluoro-1,4-pregnadiene-11-beta,17-alpha,21-triol-3,20-dione;16-alpha-methyl-9-alpha-fluoro-11-beta,17-alpha,21-trihydroxypregna-1,4-dien;16alpha-Methyl-9alpha-fluoro-11beta-17alpha-21-trihydroxypregna-1,4-diene-3,20-dione;16-alpha-methyl-9-alpha-fluoro-1-dehydrocortisol
CAS: 50-02-2
MF: C22H29FO5
MW: 392.46
EINECS: 200-003-9
Product Categories: Active Pharmaceutical Ingredients;Antitumors for Research and Experimental Use;Biochemistry;Hydroxyketosteroids;Steroids;Intermediates & Fine Chemicals;Pharmaceuticals;Isotope Labeled Compounds;Steroid and Hormone;Pharmaceutical intermediate;API;MAXIDEX;Hormone Drugs;Mainly used for anti-inflammatory and allergy
MP: 262-264 °C(lit.)
Alpha: 75 o (c=1, dioxane)
Refractive index: 76 ° (C=1, Dioxane)
Storage temp: 2-8°C
Solubility ethanol: 1 mg/mL
Form: powder
Color: off-white
Water Solubility: 10 mg/100 mL (25 oC)
Merck: 14,2943
BRN: 2066651
Stability: Stable. Combustible. Incompatible with strong oxidizing agents, strong bases, acid anhydrides, acid chlorides. May be light sensitive.
Chemical Properties: White Crystalline Solid
Usage1: A glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase
Usage2: Dexamethasone is a glucocorticoid used as an anti-inflammatory agent. Dexamethasone regulates T cell survival, growth, and differentiation. Dexamethasone inhibits the induction of nitric oxide synthas etc.

2D Structure:

Benefits of Dexamethasone:

As an anti-inflammatory medication. Dexamethasone relieves inflammation in various parts of the body. It is used specifically to decrease swelling (edema), associated with tumors of the spine and brain, and to treat eye inflammation.

To treat or prevent allergic reactions.
As treatment of certain kinds of autoimmune diseases, skin conditions, asthma and other lung conditions.
As treatment for a variety of cancers, such as leukemia, lymphoma, and multiple myeloma.
To treat nausea and vomiting associated with some chemotherapy drugs.
Used to stimulate appetite in cancer patients with severe appetite problems.
Also used to replace steroids in conditions of adrenal insufficiency (low production of needed steroids produced by the adrenal glands).

How This Drug Works:

Corticosteroids are naturally produced by the adrenal gland in the body. Corticosteroids influence the functioning of most of the body's systems (heart, immune, muscles and bones, endocrine and nervous system). They exert a wide array of effects including effects on the metabolism of carbohydrates, protein and fats. They help to maintain balance of fluids and electrolytes.

Dexamethasone is classified as a corticosteroid (more precisely a glucocorticosteroid), and has many uses in the treatment of cancer.

One way that it works is to decrease inflammation (swelling). It does this by preventing infection- fighting white blood cells (polymorphonuclear leukocytes) from traveling to the area of swelling in your body. (This is why you are more prone to infection while taking steroids). Taking advantage of the anti-inflammatory properties of the medication, corticosteroids are used to decrease the swelling around tumors. For example, by decreasing swelling around tumors in the spine, brain, or bone, it can decrease the pressure of the tumor on nerve endings and relieve pain or other symptoms caused by the pressing tumor.

Another way this drug works is by altering the body's normal immune system responses. Corticosteroids are used to treat certain conditions that effect the immune system such as aplastic anemia (AA), Immune Thrombocytopenia Purpura (ITP), Thrombotic Thrombocytopenia Purpura (TTP), or hemolytic anemia.

In addition, it is thought that corticosteroids may help in the treatment of patients with blood disorders, such as multiple myeloma. Corticosteroids may work by causing programmed cell death (apoptosis) of certain cells, which may help to fight your disease.

Dexamethasone is also used in the short-term treatment of nausea caused by chemotherapy. How it does this is not fully understood. It also has been used to stimulate appetite for patients with severe appetite problems.

Corticosteroids are used to replace steroids in conditions of adrenal insufficiency (low production of needed steroids produced by the adrenal glands).

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