CAS 139110-80-8 Antiviral Agents Zanamivir Hydrate For Viral Influenza Treatment

CAS 139110-80-8 Antiviral Agents Zanamivir Hydrate For Viral Influenza Treatment

1. Quick Details:

2. Description:

Zanamivir is a sialic acid-analogue neuraminidase inhibitor with antiviral activity. Administered into the respiratory tract by aerosol inhalation, zanamivir selectively binds to and inhibits influenza A and B virus neuraminidase-mediated cleavage of sialic acid residues in host cell membrane-bound glycoprotein receptors for influenza viruses, preventing the release of progeny viruses from host cell surfaces and, so, further viral replication.

3. Therapeutic Uses:

Zanamivir is indicated for the treatment of uncomplicated acute illness due to influenza A virus in adults and children 7 years and older who have been symptomatic for no more than 2 days. Zanamivir must be started within 48 hours after the onset of influenza symptoms.

Zanamivir is indicated for the treatment of uncomplicated acute illness due to influenza B virus in adults and children 7 years and older who have been symptomatic for not more than 2 days. Zanamivir must be started with 48 hours after the onset of influenza symptoms.

Zanamivir is indicated for the prophylaxis of influenza A and B. Although not a substitute for influenza virus vaccine, use of zanamivir may be considered if the vaccine is not available, in conjunction with the vaccine late in the influenza season, before the vaccine has induced an immune response, or if there is not immune response to the vaccine.

3. Route of Elimination:

It is excreted unchanged in the urine with excretion of a single dose completed within 24 hours. Unabsorbed drug is excreted in the feces.Zanamivir is renally excreted as unchanged drug.

4. Mechanism of Action:

The proposed mechanism of action of zanamivir is via inhibition of influenza virus neuraminidase with the possibility of alteration of virus particle aggregation and release. By binding and inhibiting the neuraminidase protein, the drug renders the influenza virus unable to escape its host cell and infect others.

5. Matters Needing Attention:

Zanamivir is not a substitute for annual vaccination with influenza virus vaccine inactivated or influenza virus vaccine live intranasal. Although antiviral agents used for treatment or prevention of influenza (amantadine, oseltamivir, rimantadine, zanamivir) may be used concomitantly with influenza virus vaccine inactivated if indicated, influenza virus vaccine live intranasal should not be administered until at least 48 hours after influenza antiviral agents are discontinued and these antiviral agents should not be administered until at least 2 weeks after administration of influenza virus vaccine live intranasal.

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