Treatment of Breast Cancer Anti Estrogen Steroids Fulvestrant Powder CAS 129453-61-8

Treatment of Breast Cancer Anti Estrogen Steroids Fulvestrant Powder CAS 129453-61-8

Description:

Fulvestrant is known as a hormonal breast cancer treatment. It is used to treat advanced breast cancer and metastatic breast cancer. Advanced breast cancer is cancer which has progressed despite treatment, and metastatic breast cancer is cancer which has spread into other parts of the body.

Many breast cancers need the female hormone oestrogen to grow. The cells of these cancers have tiny areas called receptors on their surface, which oestrogen can attach to. They are called 'hormone receptor-positive' cancers. Fulvestrant works by blocking the receptors and this prevents oestrogen from reaching the cancer cells. This slows the growth of the cancer.

Specifications:

Chemical Names: Fulvestrant; Faslodex; 129453-61-8; ICI 182,780; Ici 182780; ICI-182780 More...
Molecular Formula: C32H47F5O3S
Molecular Weight: 606.777 g/mol
CAS: 129453-61-8
Density: 1.201 g/cm3
Melting Point: 104-106°C
Boiling Point: 674.8 °C at 760 mmHg
Appearance: white powder
Storage condition: 2-8°C
Usage: Antineoplastic (hormonal)

2D Structure:

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COA:

Uses:

Fulvestrant is used to treat breast cancer that has spread to other areas of the body in women who have gone through "the change of life" (menopause). It is used in patients who have not responded well to other medications (e.g., tamoxifen). Breast cancer cells need the hormone estrogen in order to grow. Fulvestrant works by blocking the effect of estrogen, slowing tumor cell growth.

How Fulvestrant Works:

Many breast cancers are stimulated to grow by the female sex hormones oestrogen and progesterone. These breast cancers are called hormone sensitive or hormone receptor positive. Drugs that block the effects of these hormones can slow or stop the growth of the breast cancer cells. Fulvestrant stops oestrogen getting to the cancer cells by blocking oestrogen receptors and reducing the number of receptors the cancer cells have.

Possible Side Effects of fulvestrant (Faslodex):

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

headache, back pain;
bone pain, joint pain, muscle pain;
vomiting, loss of appetite, constipation;
weakness, feeling tired;
cough, trouble breathing;
pain in your arms or legs;
hot flashes; or
pain where the medicine was injected.

Before Taking Fulvestrant:

tell your doctor and pharmacist if you are allergic to fulvestrant or any other medications.
tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention anticoagulants (blood thinners) such as warfarin (Coumadin). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
tell your doctor if you have or have ever had any bleeding problems or liver disease.
you should know that fulvestrant should only be taken by women who have undergone menopause and cannot become pregnant. However, if you are pregnant, you should tell your doctor before you begin treatment with this medication. Your doctor may also check to see if you are pregnant before you begin treatment. Tell your doctor if you become pregnant during your treatment with fulvestrant. Fulvestrant may harm the fetus.
tell your doctor if you are breast-feeding. You should not breast-feed during your treatment with fulvestrant.

How This Drug is Given?

As an injection into the muscle (intramuscular, IM).
Fulvestrant is usually given as a once a month injection. Your doctor will determine any variations to this dosing or schedule.
Usual Adult Dose for Breast Cancer:Initial dose: 500 mg IM on days 1, 15, and 29, then once a month thereafter.

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