Local Anesthetic Drugs Procaine CAS 59-46-1 Novocaine Pharma Raw Materials

Local Anesthetic Drugs Procaine CAS 59-46-1 Novocaine Pharma Raw Materials

Procaine, also known as novocaine, is a local anesthetic used in association with penicillin. Local anesthetics numb a specific region of the body, whereas a general anesthetic desensitizes the entire body. When a doctor injects penicillin directly into muscle, it can be very painful for the patient, but numbing the injection site with procaine may decrease the discomfort. Patients also may receive the anesthetic during minor surgery or dental work to cause a lack of sensitivity in areas of skin and mucous membranes.

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2. What Is Procaine?

This anesthetic is sold under the brand name Novocain for commercial use. People sometimes refer to generic procaine as novocaine because of the trade name’s popularity. The term novocaine is particularly popular when associated with dentistry, in which the local anesthetic properties numb the mouth before dental procedures.

Originally synthesized in 1905, procaine replaced cocaine as the most frequently employed local anesthetic. The introduction of procaine was a key step in the progression of anesthetics because it was less dangerous and more effective than its predecessors. When used as an anesthetic, cocaine gave patients unnecessary feelings of euphoria. Additionally, the risk of addiction and misuse associated with cocaine were not shared with procaine, making it a safer option for medical treatment.

Formally referred to as procaine benzylpenicllin, procaine penicillin is a combination of the anesthetic and a type of penicillin. The purpose of the mixture is to lessen the pain of a deep muscle injection. Veterinarians use the shots more than physicians because other medications, such as lidocaine, are more effective when used by humans. Doctors still find the combination useful for patients, particularly during syphilis treatments.

3. How Does Procaine Work?

Procaine temporarily prevents the sense organs from initiating afferent impulses and provides regional analgesia.It works by producing a trigeminal nerve conduction block, in the mandibular branch, decreasing the permeability of the axon cell membrane to (Na+) sodium ions.This mechanism prevents the entry of Na+ ions into the axon to propagate an action potential in both slow and fast pain fibers.Unmyelinated axons are the first to be affected.Myelinated motor nerves are only affected at the nodes of Ranvier.Procaine works to anesthetize a patient for about 15 minutes.To prolong anesthesia epinephrine is added as a vasoconstrictor.

4. Who Should Not Take This Medication?

People who have experienced allergy to the drug should not take it.Fortunately, true allergic reaction to procaine is rare. However, adverse reactions (anesthetic overdose, fainting) appear to be common.Differentiating between allergic reactions and resistance to the drug is often difficult because of the similarity of the symptoms.Thus, many physicians are conservative and label patients as "allergic" to all "caine" drugs even when the signs and symptoms are consistent with an adverse reaction.Unfortunately, this conservative decision often results in the patient being denied the comfort of a local anesthetic when desirable.

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