Pharmaceutical Intermediates Dutasteride Avodart For Treat Hair Loss / Prostate Enlargement

Pharmaceutical Intermediates Dutasteride Avodart For Treat Hair Loss / Prostate Enlargement

Dutasteride is a synthetic drug used to treat hair loss and prostate enlargement in men. Its mechanism of action is to suppress 5-alpha-reductase (5 ar), the enzyme responsible for the conversion of testosterone into dihydrotestosterone (DHT). While male-pattern baldness and benign prostatic hyperplasia (BPH) are both provoked by this biological event, the Food and Drug Administration (FDA) only approves dutasteride to treat the latter in the U.S. However, it is expected that clinical trials currently underway will result in the drug becoming officially FDA approved to treat hair loss too, as well as being approved as a cancer of the prostate drug.

1. Quick Details:

2. Description of Dutasteride:

Dutasteride is considered to be a dual 5-alpha-reductase inhibitor because it suppresses both isoforms of the enzyme. This gives the drug an advantage over similar medications, such as finasteride, which only prevent the release of one. As a result of this enhanced activity, dutasteride is more effective at inhibiting DHT synthesis than finasteride-based medications, otherwise known as Propecia or Proscar.

There are also fewer side effects reported with dutasteride than there are with finasteride. In addition, studies have shown that these side effects are usually temporary and tend to diminish over time. The most commonly experienced side effects in the order of frequency from highest to lowest include impotence, decreased interest in sex, difficulty ejaculating, and gynecomastia, or tenderness in the breast.

There is one more consequence sometimes experienced with taking this medication that’s known as Dutasteride Shedding. It is actually more of a normal part of the hair restoration process than it is a side effect. It occurs as the drug stimulates hair follicles to abandon a state of rest and produce new growth. However, while many hairs that have entered into this resting phase are still attached to the follicle, they receive no nourishment and do not grow -- they are essentially dead. This means that many hairs may need to fall out at the same time before any new growth can be seen, a process that can take anywhere from six weeks to two months.

3. What Dutasteride Is Used for:

Prostate enlargement, male pattern hair loss, seborrheic alopecia, hereditary hair loss.

Dutasteride, along with Finasteride is a 5-alpha-Reductase inhibitor which are a group of drugs with anti-androgenic properties which inhibit the conversion of testosterone into dihydrotestosterone (DHT). This is the same chemical found in Proscar and Propecia and is used in the treatment hyperplasia and androgenic alopecia. Because these drugs reduce levels of dihydrotestosterone (DHT) they are used to prevent and treat hairloss. It is most commonly used to treat enlarged prostate glands.

4. How to Take Dutasteride (Dosage):

Oral Capsule

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

• your age
• the condition being treated
• how severe your condition is
• other medical conditions you have
• how you react to the first dose

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