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|Melting Point:||168-172 ºC||Appearance:||White Crystalline Powder|
Local Anesthetic Agents,
Local Anesthetic Powder
Fever Reducer Local Anesthetic Drugs Paracetamol / 4-Acetamidophenol Powder 103-90-2
Paracetamol is a commonly used medicine that can help treat pain and reduce a high temperature (fever). It's typically used to relieve mild or moderate pain, such as headaches, toothache or sprains, and reduce fevers caused by illnesses such as colds and flu.
Paracetamol is often recommended as one of the first treatments for pain, as it's safe for most people to take and side effects are rare.
English name: 4-Acetamidophenol
Synonyms: Acetaminophen; 4-Hydroxyacetanilide; Paracetamol; APAP; p-Hydroxyacetanilide; 4-Acetamino phenol; Acetaminphen; Paracetamol DC; N-Acetyl-4-aminophenol; N- (4-hydroxyphenyl) acetamide; Acetamiophen
EINECS Number: 203-157-5
Water-soluble: 14 g / L (20 ºC)
Melting point: 168-172 ° C
Water-soluble: 14 g / L (20 ° C)
Appearance: White crystalline powder
|Appearance||White or almost white ,crystalline powder.||White,crystalline powder.|
|Water||Not more than0.5%||0.08%|
|Related substance||Impurity(chloroacetanilide)not more than 10 ppm||2ppm|
|Impurity K(4-aminophenol)not more than 50 ppm||15 ppm|
|Impurity F(4-nitrophenol)not more than 0.05%||Not detected|
|any other impurity not more than 0.05%||0.01%|
|Total of other impurities not more than 0.1%||0.02%|
|Residue on ignition||Not more than 0.1%||0.05%|
|Chloride||Not more than 0.014%||Less than 0.014%|
|Sulfate||Not more than 0.02%||Less than 0.02%|
|Heavy metals||Not more than 0.001%||Less than 0.001%|
|Free p-aminophenol||Not more than 0.005%||Less than 0.005%|
|Limit of Pchloroa
|Not more than 0.001%||Less than 0.001%|
|Readily carbonizable substances||Conforms||Conforms|
|Residual solvents||Residual content of acetic acid is limited by the test of loss on dryingnot more than0.5%||0.08%|
|Conclusion: Complies with USP34 / BP2011|
1. Medical uses:
Paracetamol is used for reducing fever in people of all ages. The World Health Organization (WHO) recommends that paracetamol be used to treat fever in children only if their temperature is greater than 38.5 °C (101.3 °F). The efficacy of paracetamol by itself in children with fevers has been questioned and a meta-analysis showed that it is less effective than ibuprofen.
Paracetamol is used for the relief of mild to moderate pain. The use of the intravenous form for pain of sudden onset in people in the emergency department is supported by limited evidence.
The American College of Rheumatology recommends paracetamol as one of several treatment options for people with arthritis pain of the hip, hand, or knee that does not improve with exercise and weight loss.A 2015 review, however, found it provided only a small benefit in osteoarthritis.
Paracetamol has relatively little anti-inflammatory activity, unlike other common analgesics such as the NSAIDs aspirin and ibuprofen, but ibuprofen and paracetamol have similar effects in the treatment of headache. Paracetamol can relieve pain in mild arthritis, but has no effect on the underlying inflammation, redness, and swelling of the joint.It has analgesic properties comparable to those of aspirin, while its anti-inflammatory effects are weaker. It is better tolerated than aspirin due to concerns about bleeding with aspirin.
Low back pain
Based on a systematic review, paracetamol is recommended by the American College of Physicians and the American Pain Society as a first-line treatment for low back pain.However, other systematic reviews concluded that evidence for its efficacy is lacking.
A joint statement of the German, Austrian, and Swiss headache societies and the German Society of Neurology recommends the use of paracetamol in combination with caffeine as one of several first line therapies for treatment of tension or migraine headache.In the treatment of acute migraine, it is superior to placebo, with 39% of people experiencing pain relief at 1 hour compared to 20% in the control group.
Paracetamol combined with NSAIDs may be more effective for treating postoperative pain than either paracetamol alone or NSAIDs alone.
The efficacy of paracetamol when used in combination with weak opioids (such as codeine) improved for approximately 50% of people but with increases in the number experiencing side effects.Combination drugs of paracetamol and strong opioids like morphine improve analgesic effect.
The combination of paracetamol with caffeine is superior to paracetamol alone for the treatment of common pain conditions including dental pain, postpartum pain, and headache.
2. Veterinary use:
Paracetamol has also been widely used in the veterinary area, the effect has been proved by the treatment of cats, dogs, snakes, and other animals without or with rare side effects.
How to Take Paracetamol?
How much you can take depends on your age, your weight, the type of paracetamol you're taking and how strong it is. For example:
Adults can usually take one or two 500mg tablets every 4-6 hours, but shouldn't take more than 4g (eight 500mg tablets) in the space of 24 hours.
Children under 16 need to take a lower dose, depending on their age or weight - check the packet or leaflet, or ask a pharmacist or doctor for advice. For very young children, paracetamol liquid is given using a measuring spoon or an oral syringe.
Paracetamol should start to work within an hour and the effect usually lasts several hours. Don't take more than the recommended dose if it isn't relieving your symptoms.
Adults can take ibuprofen at the same time if necessary, but this isn't usually recommended for children.
A: Keep out of the reach and sight of children.
B: Store below 25° C in a dry place, protected from light.
C: Do not use Paracetamol tablets after the expiry date stated on the label/carton/bottle. The expiry date refers to the last day of that month.
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