Premature Ejaculation PE Hydrochloride CAS 119356-77-3 White Solid

Premature Ejaculation PE Hydrochloride CAS 119356-77-3 White Solid

, marketed as and Westoxetin, among and other brands, is the first compound developed specially for the treatment of premature ejaculation (PE) in men 18-64 years old. works by inhibiting the serotonin transporter, increasing serotonin's action at the post synaptic cleft, and as a consequence promoting ejaculatory delay.As a member of selective serotonin reuptake inhibitor (SSRI) family, was initially created as an antidepressant. However, unlike other SSRIs, is absorbed and eliminated rapidly in the body. Its fast acting property makes it suitable for the treatment of PE but not as an antidepressant.

1. Quick Details:

2. What Is Hydrochloride?

hydrochloride is a drug that is used to treat premature ejaculation in men. It is available by prescription and is taken orally, prior to sexual intercourse. The drug belongs to the class called serotonin reuptake inhibitors (SSRIs), which have mainly been used to treat depression.

Sexual dysfunction, including premature ejaculation, is an extremely common condition worldwide. The cause of premature ejaculation has not been fully elucidated, but may include both psychological and physiological factors. Premature ejaculation refers to a short ejaculation time, which can affect the satisfaction of both partners during sexual intercourse.

To treat premature ejaculation, both psychological and physiological factors need to be managed. From a pharmacological point-of-view, to treat the physiological aspect of premature ejaculation, hydrochloride is one of the first oral drugs to be made available. Psychological treatment may be given concomitantly, as the condition is multifactorial.

One of the possible adverse effects reported with SSRIs when used to treat depression is delayed ejaculation. This reported adverse effect led to the studies of hydrochloride, using the effect therapeutically. It is thought that serotonin may be involved in the inhibition of ejaculation. By blocking the serotonin reuptake in men suffering from premature ejaculation, the time to ejaculation may be prolonged.

3. Premature ejaculation (PE) and Hydrochloride:

Premature ejaculation (PE) is the most common male sexual dysfunction. hydrochloride, belonging to a class of drugs known as selective serotonin reuptake inhibitors or, was the first drug originally approved for the on-demand treatment of men with PE. We aimed to compare the intravaginal ejaculatory latency time (IELT), patient-reported global impression of change (PGIC), and adverse effect (AE) incidence associated with the use of (30?mg and 60?mg) versus placebo, and evaluate the differences in administering 60?mg versus 30?mg as on-demand medical oral therapy for the treatment of PE via a literature review and meta-analysis. Relevant randomized controlled trials (RCTs) were identified from PubMed, EMBASE, and Cochrane Central Register of Controlled Trials (Cochrane Library) databases. Ultimately, a total of seven RCTs with 8039 patients were included. Our meta-analysis demonstrated that (in the 30?mg and 60?mg subgroup) resulted in significantly higher IELT, PGIC, and AE incidence relative to the placebo, with higher proportions observed for 60?mg versus 30?mg of administration. The most common AEs were mild and tolerable. We conclude that (particularly the 60?mg dosage) may be considered a safe and effective drug for patients with PE.

4. Dosage:

For premature ejaculation and erectile dysfunctions (Adults):

The recommended adult dose of hydrochloride is 30 - 60 mg/day. The maximum dose should not exceed 100 mg/day. Take hydrochloride at least two hours before sexual intercourse to achieve maximum treatment benefits.

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