Payment & Shipping Terms:
|Tablets Standard:||50 Mg, 100 Mg, Or 200 Mg||Appearance:||White Crystalline Powder|
Synthetic Anabolic Steroids,
Legal Synthetic Steroids
Oral Anabolic Steroids Sex Drug Avanafil Raw Powder CAS: 330784-47-9 for Treating ED
Avanafil is an oral drug that is used for treating impotence (the inability to attain or maintain a penile erection), also known as erectile dysfunction (ED). It is in a class of drugs called phosphodiesterase inhibitors that also includes tadalafil (Cialis), sildenafil (Viagra) and vardenafil (Levitra).
Product name: Avanafil
Trade name: Stendra
Molecular formula: C23H26ClN7O3
Molecular weight: 483.95
Solubility: slightly soluble in ethanol, practically insoluble in water, and soluble in 0.1 mol/L hydrochloric acid.
Tablets standard: 50 mg, 100 mg, or 200 mg
Appearance: white crystalline powder
Storage: Store in a cool, dry place, away from direct heat and light.
|Description||White or Almost White Crystalline Powder||white powder|
|Loss On Drying||1.0%max||0.28%|
|Organic Volatile Impurities||meets the requirement.||Conforms|
|Related Substances||meets the requirement.||Conforms|
|Residual Solvents||meets the requirement.||Conforms|
|Particle Size||100% ≤ 20 microns||Conforms|
Avanafil is a PDE5 inhibitor approved for erectile dysfunction by the FDA on April 27, 2012 and by EMA on June 21, 2013. Avanafil is known by the trademark names Stendra and and was developed by Vivus Inc. In July 2013 Vivus announced partnership with Menarini Group, which will commercialise and promote in over 40 European countries plus Australia and New Zealand.Avanafil acts by inhibiting a specific phosphodiesterase type 5 enzyme which is found in various body tissues, but primarily in the corpus cavernosum penis, as well as the retina.Other similar drugs are sildenafil, tadalafil and vardenafil. The advantage of avanafil is that it has very fast onset of action compared with other PDE5 inhibitors. It is absorbed quickly, reaching a maximum concentration in about 30-45 minutes.About two-thirds of the participants were able to engage in sexual activity within 15 minutes.
Advantage of Avanafil:
This medication's advantage is that it works much faster than other erection-inducing drugs. For example, Viagra generally takes about an hour to induce a good erection, and probably longer than that if the man has a lot of food in his stomach.
Cialis and Levitra also tend to take about an hour to work. This type of delay can make it rather difficult to enjoy a really spontaneous sex life.
In contrast, avanafil is absorbed very rapidly. It reaches a maximum bloodstream concentration in under 45 minutes. It is said that most men can get an erection with 15 minutes of swallowing the tablet.
How Does Avanafil Work?
Erection of the penis is caused by the filling of the penis with blood. Filling occurs because the blood vessels that bring blood to the penis increase in size and deliver more blood to the penis, and, at the same time, the blood vessels that take blood away from the penis decrease in size and remove less blood from the penis. Sexual stimulation that leads to an erection causes the production and release of nitric oxide in the penis. The nitric oxide causes an enzyme, guanylate cyclase, to produce cyclic guanosine monophosphate (cGMP). It is cGMP that is primarily responsible for increasing and decreasing the size of blood vessels carrying blood to and from the penis, respectively, and causing an erection. When the cGMP is destroyed by another enzyme, phosphodiesterase-5, the blood vessels return to their normal size, blood leaves the penis, and the erection ends. Avanafil prevents phosphodiesterase-5 from destroying cGMP so that cGMP stays around longer. The persistence of cGMP leads to a more prolonged engorgement of the penis with blood. Avanafil was approved by the FDA in April 2012.
Before Taking Avanafil:
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking avanafil it is important that your doctor knows:
If you have any disease, injury or deformity of your penis.
If you have an irregular heartbeat, a heart condition, or blood vessel disease.
If you have had an eye condition causing loss of vision.
If you have high or low blood pressure, or angina.
If you have any problems with the way your liver works or with the way your kidneys work.
If you have had a stroke or a heart attack.
If you have a condition which causes bleeding, such as a stomach ulcer.
If you have sickle cell disease.
If you have ever had bone marrow cancer or leukaemia.
If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines, and recreational drugs.
If you have ever had an allergic reaction to a medicine.
How to Take Avanafil:
Take avanafil exactly as your doctor tells you to. It is intended to be taken before sexual activity - it is NOT for continuous daily use. You should take one tablet about 15-30 minutes before you plan to have sex. You can take the tablet either before or after food but, if you have just eaten a meal, it may take longer for it to work.
There are three strengths of avanafil tablets: 50 mg, 100 mg and 200 mg. It is likely that you will be given the 100 mg strength tablet to begin with, but this may be changed subsequently depending upon how you react. Each time you collect a prescription, check to make sure it contains the strength of tablet you are expecting.
Do not take more than one dose of avanafil in any 24-hour period.
If you have any question pls feel free to contact me via: