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CAS no.136-47-0 Tetracaine HCl for Pain Killer , Injectable Local Anesthetics
Product Details:
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Detailed Product Description
| Name: | Tetracaine HCl | CAS: | 136-47-0 |
|---|---|---|---|
| Appearance: | White Or Almost White Crystalline Powder | Assay: | 99.3% |
| Shipping Methods: | EMS, DHL, FEDEX, USPS, TNT, HK Post | Payment Terms: | TT, , MONEY GRAM, BITCOIN |
| Packaging: | Professional Disguised Packaging | Delivery Time: | 2--6 Working Days |
| Pass Rate: | More Than 99% With Best Reship Policy | ||
| High Light: | Local Anesthetic Agents,Injectable Local Anesthetics |
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Product Description
Most Popular Tetracaine HCL CAS: 136-47-0 For Pain Killer With Safe Delivery
COA:
| Product Name | tetracaine hydrochloride |
| Alias | Tetracaine HCl; 2-dimethylaminoethyl 4-n-butylaminobenzoate hydrochloride; 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester hydrochloride |
| CAS Registry Number | 136-47-0 |
| Einecs No | 205-248-5 |
| Molecular Formula | C15H25ClN2O2 |
| Molecular Weight | 300.8242 |
| Flash Point | 189.3°C |
| Appearance | white powder |
| Boiliing Point | 389.4°C at 760 mmHg |
| Vapor Pressure | 2.87E-06mmHg at 25°C |
COA:
| Test Items | Specification | Test Results |
| Appearance | Fine, white, crystalline, odorless powder | confirm |
| Identification | ABC in Pass | confirm |
| Solubility | Very soluble in water, soluble in Alcohol; insoluble in Ether and Benzene |
confirm |
| USP Reference standards | USP Tetracaine Hydrochloride RS. USP Endotoxin RS. |
confirm |
| Melting point | 145~150 degree | 146.0~147.5 degree |
| Chromatographic purity | In Pass | confirm |
| Related substance | Not more than the reference solution 0.05% | confirm |
| Heavy metals | ≤10ppm | confirm |
| PH | 4.5-6.5 | 5.8 |
| Residue on ignition | ≤0.10% | 0.05% |
| Loss on Drying | ≤ 0.5% | 0.19% |
| Assay | 98.0 -101.0% | 100.1% |
| Conclusion | Confirms USP 32 | |
Product Description:
Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.
Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
Product Application:
A- For block anesthesia and epidural anesthesia.
B- Also used for ventricular arrhythmias caused by myocardial infarction, digitalism, glucantime poisoning, surgery and so on. Such as ventricular tachycardia, frequent ventricular premature beat, ventricular fibrillation.
C- As painkillers of injection in the medicament.
D- Also used in suppository and ointment preparation, etc.
Tetracaine (also known as amethocaine) is a local anesthetic of the ester anesthetic group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
Tetracaine is the T in TAC, a mixture of 5 to 12% tetracaine, 0.05% adrenaline, and 4 or 10% cocaine hydrochloride used in ear, nose, and throat surgery and in the emergency department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, ear, or other sensitive locations.
It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system.
A systematic review investigated tetracaine for use in emergency departments, especially for intravenous cannulation in children, in view of its analgesic and cost-saving properties. However, it did not find an improvement in first-attempt cannulations.
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