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|Storage:||Shading, Confined Preservation||Usage:||Used For Pharmaceutical Materials|
|Molecular Formula:||C18H28N2O||Molecular Weight:||288.43|
|Packing:||Discreet Diguised Package Or As Require||Appearance:||White Powder|
Local Anesthetic Agents,
Injectable Local Anesthetics
Local anesthetics Bupivacaine Marcaine 99% purity powder CAS: 2180-92-9
Product Name: Bupivacaine
Synonyms: MARCAINE;BUPIVACAINE;BUPIVACAINE BASE
Bupivacaine, marketed under the brand name Marcaine among others, is a medication used to decrease feeling in a specific area. It is used by injecting it into the area, around a nerve that supplies the area, or into the spinal canal's epidural space. It is available mixed with a small amount of epinephrine to make it last longer. It typically begins working within 15 minutes and lasts for 2 to 8 hours.
Possible side effects include sleepiness, muscle twitching, ringing in the ears, changes in vision, low blood pressure, and an irregular heart rate. Concerns exist that injecting it into a joint can cause problems with the cartilage. Concentrated bupivacaine is not recommended for epidural freezing. Epidural freezing may also increase the length of labor. It is a local anaesthetic of the amide group.
Bupivacaine is indicated for local infiltration, peripheral nerve block, sympathetic nerve block, and epidural and caudal blocks. It is sometimes used in combination with epinephrine to prevent systemic absorption and extend the duration of action. The 0.75% (most concentrated) formulation is used in retrobulbar block. It is the most commonly used local anesthetic in epidural anesthesia during labor, as well as in postoperative pain management.
Bupivacaine is contraindicated in patients with known hypersensitivity reactions to bupivacaine or amino-amide anesthetics. It is also contraindicated in obstetrical paracervical blocks and intravenous regional anaesthesia (Bier block) because of potential risk of tourniquet failure and systemic absorption of the drug and subsequent cardiac arrest. The 0.75% formulation is contraindicated in epidural anesthesia during labor because of the association with refractory cardiac arrest.
CERTIFICATE OF ANALYSIS
|CAS No.||2180-92-9||Outer Packing|
|Production date||2017.09.13||Shelf life||2019.09.12|
|Standard adopted||Enterprise standard|
|Items of analysis||Specification||Results|
|White or off white crystalline powder||Complies|
|Solubility||reely soluble in Dichloromethane, soluble in ethanol, and Ethyl acetate, insoluble in water.||Complies|
IR ;The retention time of the major peak in the choramtogram of the Assay preparation corresponds to that in the
|Loss on drying||≤ 0.5%||0.03%|
|any individual impurity||not more than 0.3%||0.05%|
|total impurities||not more than 0.5%||0.06%|
|Limit of residual solvents||Conform to standard||Complies|
|Residue on ignition||≤0.1%||0.03%|
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