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|Alias:||Serophene; Pergotime; Clomphid; Clomid||Appearance:||White Or Milky White Crystalline Powder|
|Molecular Weight:||598.08||CAS Register Number:||50-41-9|
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Clomid (Clomiphene Citrate) is a powerfully effective anti-estrogen officially classified as a Selective Estrogen Receptor Modulator (SERM). In many ways, it is very similar to another popular SERM in Nolvadex (Tamoxifen Citrate). Clomid first gained worldwide attention in the early 1970’s as a strong fertility aid and is still used for that purpose today. It is also one of the most commonly used SERM’s by anabolic steroid users. No, it is not an anabolic steroid but can be used to combat estrogenic side effects sometimes caused by anabolic steroids. It can also be used as a Post Cycle Therapy (PCT) medication in order to stimulate suppressed testosterone production due to anabolic steroid use. PCT use of Clomid is the most common purpose and most beneficial point of use for the anabolic steroid user.
Product Specification :
Product name Clomifene Citrate
Alias: serophene; pergotime; clomphid; Clomid
Another name: 2-4-[2-Chloro-1,2-diphenylethenyl]phenoxy-N,N-diethylethanamine citrate
CAS register number 50-41-9
Appearance: white or milky white crystalline powder. Melting point 116.5-118, slightly soluble in ethanol, chloroform, water, insoluble in ether.
Molecular formula C32H36ClNO8
Molecular weight 598.08
Usage: the goods to anti-estrogen fertility inducer, the objects in dysfunctional uterine bleeding, polycystic ovary, menstrual disorders and drug-induced amenorrhea and other gynecologic diseases.
Synonyms: Clomiphene Citrate;clomifene citrate;clomphid;clomid;Fertyl;clomivid;Fertivet;anti estrogen hormones;Chloramiphene; serophene; pergotime; clomphid; Clomid
|Test Items||Specification||Test Results|
|Appearance||White or off-white powder||white powder|
|Water||Not more than 1.0%||0.35%|
|Heavy water||Not more than 0.002%||Conforms|
|Related impuries||Related compound A:Not more than 2.0%||0.84%|
|Individual:Not more than 0.5%||0.36%|
|Conclusion||This batch is complies with USP 32.|
Clomid is the commonly referenced brand name for the drug clomiphene citrate. It is not an anabolic steroid, but a prescription drug generally prescribed to women as a fertility aid. This is due to the fact that clomiphene citrate shows a pronounced ability to stimulate ovulation.
This is accomplished by blocking/minimizing the effects of Clomiphene Citrate estrogen in the body. To be more specific Clomid is chemically a synthetic estrogen with both agonist/antagonist properties, and is very similar in structure and action to Clomiphene Citrate Nolvadex. In certain target tissues it can block the ability of estrogen to bind with its Clomiphene Citrate corresponding receptor. Its clinical use is therefore to oppose the Clomiphene Citrate negative feedback of estrogens on the hypothalamic-pituitary-ovarian axis, which enhances Clomiphene Citrate the release of LH and FSH. This of course can help to induce ovulation.
How should clomiphene citrate be used?
Clomiphene citrate may be used alone or in combination with other medical therapies. The United States Food and Drug Administration-approved initial dosage is 50 mg daily for 5 days per cycle. The dose may be increased to 100 mg daily (2 50-mg tablets taken together as a single dose) for 5 days per cycle if patients do not ovulate in response to 50 mg daily. The prescribing information recommends starting therapy about 5 days after spontaneous or induced menses or at any time if the patient has had no recent uterine bleeding.17 However, Wu et al18 showed similar ovulatory and pregnancy rates with initiation of clomiphene citrate as early as cycle day .
Ovulation is expected 5 to 10 days after the last dose of clomiphene citrate.17 The timing of sexual intercourse in relation to ovulation has been shown to influence the chance of conception in the general population.19 Some clinicians advise couples to have intercourse a minimum of twice a week or every other day during the week of ovulation; however, no supporting data exist regarding a specific coitus schedule for women taking clomiphene citrate. Coitus should ideally be planned to coincide with the expected time of ovulation.17,19 In properly selected women, approximately 46% will ovulate while using the 50-mg per day dosage, and approximately another 21% will ovulate if the dosage is increased to 100 mg.
Although the prescribing information states that dosages higher than 100 mg daily are not recommended,17 some clinicians continue to titrate up in 50-mg increments until ovulation is achieved. Once the minimum effective dose has been determined, the patient may attempt to conceive for 6 to 9 cycles.21 There is no benefit to increasing the clomiphene citrate dose in subsequent cycles beyond the minimum dose at which ovulation occurs. If the patient does not ovulate at a maximum clomiphene citrate dosage of 150 mg daily, alternative approaches to ovulation induction should be considered because the incremental ovulatory rate for dosages higher than 150 mg daily for 5 days is minimal.
Some clomiphene citrate-resistant anovulatory wo-men may require higher doses of 200 to 250 mg for an extended period of time, usually 8 to 10 days.23 This can be considered prior to second-line agents such as exogenous gonadotropins, but may delay time to ovulation and conception. Antiestrogenic side effects become more common at higher doses.
The Practice Committee of the American Society of Reproductive Medicine (ASRM) also states that clomiphene citrate treatment should be limited to the minimum effective dose and to no more than 6 ovulatory cycles.
After initiation of therapy, response can be measured by BBT, urinary LH excretion using commercial kits, or serial transvaginal ultrasound (TVUS) examinations. There is little data to suggest that monitoring improves conception rates. The use of high-technology monitoring such as TVUS in initial attempts at ovulation induction with clomiphene citrate only increases costs and does not seem to offer an advantage over low-technology monitoring in improving conception rates.
1 gram of Clomiphene Citrate
1 beaker suitable for holding the volume of liquids
7.6 ml of Glycerol
11.3 ml of 190 Proof Grain Alcohol
Powder: per 1 gram of Clomiphene Citrate
Produces: Highest concentration made - 50 mg/ml
1 gram of Clomiphene Citrate
1 beaker suitable for holding the volume of liquids
8.4 ml of PEG 600
10.5 ml of 190 Proof Grain Alcohol
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