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|MW:||410.45||Synonyms:||CORTEXILAR; FLUCORT; FLUMETHASONE; ANIPRIME|
Local Anesthetic Agents,
Local Anesthetic Powder
Healthy Glucocorticoid Flumethasone CAS: 2135-17-3 for Anti-inflammatory White Drug Raws
Flumetasone (INN; or flumethasone) is a corticosteroid for topical use. Trade names include Locacorten, Locorten, and Orsalin. It is available in combination with clioquinol, under the trade name Locacorten-Vioform (in some countries Locorten-Vioform), for the treatment of otitis externa and otomycosis. It is usually formulated as the pivalic acid ester prodrug flumetasone pivalate.
Flumethasone is 420 times as potent as cortisone in an animal model for anti-inflammatory activity.
Product name: Flumethasone
Synonyms: CORTEXILAR; FLUCORT; FLUMETHASONE; ANIPRIME
Assay: 99% min.
Packing: 1 kg/foil bag or tin.
Character: White or white crystalline powder.
Usage A glucocorticoid. An anti-inflammatory.
Items of analysis
|Description||White crystalline powder||White crystalline powder|
|Identification(HPLC)||complies with the standard||complies|
|Specific optical rotation||+66º~+74º||+71.9º|
|Loss on drying||not more than 0.5%||0.06%|
|Impurity at RRT 1.11||not more than 0.15%|
|Impurity at RRT 1.39||not more than 0.15%||0.06%|
|Any unknoen Impurity||not more than 0.2%|
|Total impurities||not more than 1.0%||0.37%|
|Purity||no less than 99.0%||99.6%|
Flumethasone pivalate is a topical difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. A prompt decrease in inflammation, exudation and itching is experienced after application. It is commonly used in veterinary practice and has been used in cortisol assays to study early porcine conceptus development.
Flumethasone is a glucocorticoid receptor agonist used in studies on plasma transcortin binding. It binds to the nucleus causing a variety of genetic activation and repressions. The anti-inflammatory actions of flumethasone is thought to involve lipocortins and phospholipase A2 inhibitory proteins, which results in the inhibition of arachidonic acid and the control of prostaglandin and leukotriene biosynthesis. Flumethasone suppresses the immune system due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding.
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