Healthy Oral Anabolic Steroids Drug Dutasteride / Avodart 164656-23-9 for Anti-Hair Loss

Healthy Oral Anabolic Steroids Drug Dutasteride / Avodart 164656-23-9 for Anti-Hair Loss

Description:

Dutasteride, sold under the brand name Avodart among others is used in men to treat the symptoms of an enlarged prostate (benign prostatic hyperplasia-BPH) and androgenetic alopecia (pattern hair loss). It works by reducing the size of the enlarged prostate. This helps to relieve symptoms of BPH such as difficulty in beginning the flow of urine, weak stream, and the need to urinate frequently or urgently (including during the middle of the night). It may also reduce the need for surgery to treat BPH.

This medication should not be used by women or children.

Specifications:

Dutasteride (Avodart)
English Synonyms: (5alpha,17beta)-n-{2,5-bis(trifluoromethyl)phenyl}-3-oxo-4-azaandrost-l-ene-17-carboxamide;DUTASTERIDE;GG-745, GI-198745,;5α,17β)-N-[2,5-Bis(trifluoromethyl)phenyl]-3-oxo-4- Aza -androst-1-ene-17-carboxamide;Duagen;(5a,17)-N-[2,5-Bis(trifluoromethyl)phenyl]-3-oxo-4-azaandrost-1-ene-17-carboxamide;Avodart;GI 198745
CAS NO.: 164656-23-9
Assay: 99%
Molecular Formula: C27H30F6N2O2
Molecular Weight: 528.53
Packing:1kg/tin/foil bag
Standard: Enterprise
Appearance: White or almost white crystalline powder
Usage: Prostate enlargement, male pattern hair loss, seborrheic alopecia, hereditary hair loss.

2D Structure:

COA:

Background:

Dutasteride was developed by GlaxoSmithKline and is a 5α-reductase inhibitor which prevents the conversion of the androgen sex hormone testosterone into the more potent dihydrotestosterone (DHT).The drug has been licensed for the treatment of androgenetic alopecia in South Korea since 2009, but has not been approved for this indication in the United States,though it is commonly used off-label.

Medical Use:

1. Prostate enlargement
Dutasteride is useful for treating benign prostatic hyperplasia (BPH); colloquially known as an "enlarged prostate".

2. Prostate cancer
In those who are being regularly screened, 5α-reductase inhibitors such as finasteride and dutasteride reduce the overall risk of being diagnosed with prostate cancer; however, there is insufficient data to determine if they have an effect on the risk of death and may increase the chance of more serious cases.

3. Pattern hair loss
Dutasteride is approved for the treatment of male androgenetic alopecia in South Korea at a dosage of 0.5 mg per day. It has been found in several studies to improve hair growth in men more rapidly and to a greater extent than 2.5 mg/day finasteride.Dutasteride has also been used off-label in the treatment of female pattern hair loss.

How Dose Dutasteride Work:

Dutasteride belongs to a class of drugs called 5α-reductase inhibitors, which block the action of the 5α-reductase enzymes that convert testosterone into DHT. It is an irreversible inhibitor of all three isoforms of 5α-reductase, types I, II, and III.This is in contrast to finasteride, which is similarly an irreversible inhibitor of 5α-reductase but only inhibits the type II and III isoenzymes.As a result of this difference, dutasteride is able to achieve a reduction in circulating DHT levels of as much as 95%, whereas finasteride is only able to achieve a reduction of 70%. In spite of the differential reduction in circulating DHT levels, the two drugs decrease levels of DHT to a similar extent (approximately 85 to 90%) in the prostate gland,where the type II isoform of 5α-reductase predominates.

In addition to DHT, dutasteride prevents the 5α-reductase-mediated formation of neurosteroids such as allopregnanolone and THDOC, and 3α-androstanediol (see also neurosteroidogenesis inhibitor).These neurosteroids are potent positive allosteric modulators of the GABAA receptor and have been found to possess antidepressant, anxiolytic, and pro-sexual effects in animal research. For this reason, prevention of neurosteroid formation may be responsible for the sexual dysfunction and depression that has been associated with 5α-reductase inhibitors like dutasteride.

Do Not Use Dutasteride if:

1. you are allergic to any ingredient in dutasteride or to another 5 alpha-reductase inhibitor (eg, finasteride)
2. the patient is a woman who is pregnant or may become pregnant
3. the patient is a child

Common side effects of Avodart include:

Sexual problems (such as decreased sexual interest/ability, decrease in the amount of semen/sperm released during sex),
impotence (trouble getting or keeping an erection),
testicle pain or swelling,
increased breast size, or
breast tenderness.

Dose:

The recommended dose of Avodart is 1 capsule (0.5 mg) taken once daily. Avodart may interact with conivaptan, imatinib, isoniazid, antibiotics, antifungal medications, antidepressants, heart or blood pressure medications, or HIV/AIDS medicine. Tell your doctor all medications you use. Avodart is not usually used in women. Therefore, it is unlikely to be used during pregnancy or breastfeeding.

If you have any question pls feel free to contact me via:

Email: export@senwayer.com
Whats-app:+86-18186442580
Wickr me:yukis8888
We-chat:+86-18186442580
Tele-gram:+86-18186442580