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|CAS Number:||50-41-9||Appearance:||White Powder|
Local Anesthetic Agents,
Injectable Local Anesthetics
Effective Clomifene Citrate Raw Steroid Powders For Treating Famale Infertility , 50-41-9
Clomiphene is a long trusted oral medication relied upon for its safety, effectiveness and relatively low cost. Clomiphene is used to treat absent or irregular menstrual cycles (ovulation induction), to address a condition called luteal phase defect by increasing progesterone secretion during the second half of the cycle and to make menstrual cycle lengths more predictable, thus improving the timing of intercourse or artificial insemination. Clomiphene may also be used to enhance ovulation in women who are already ovulating (ovulation augmentation).
Another name: Clomifene citrate;CLOMIPHENE CITRATE; Clomivid; Clomphid; Ikaclomin
CAS NO: 50-41-9
Structural formula: C26H28ClNO C6H8O7
Molecular weight: 598.11
Appearance: white or milky white crystalline powder
Standard: CP USP
Use: the goods to anti-estrogen fertility inducer, the objects in dysfunctional uterine bleeding, polycystic ovary, menstrual disorders and drug-induced amenorrhea and other gynecologic diseases.
|Test Items||Specification||Test Results|
|Appearance||White or off-white powder||white powder|
|Water||Not more than 1.0%||0.38%|
|Heavy water||Not more than 0.002%||Conforms|
|Related impuries||Related compound A:Not more than 2.0%||0.86%|
|Individual:Not more than 0.5%||0.38%|
|Conclusion||This batch is complies with USP 32.|
Clomifene is useful in those who are infertile due to anovulation or oligoovulation.Evidence is lacking for the use of clomifene in those who are infertile without a known reason.In such cases, studies have observed a clinical pregnancy rate 5.6% per cycle with clomifene treatment vs. 1.3%–4.2% per cycle without treatment.
Clomifene has also been used with other assisted reproductive technology to increase success rates of these other modalities.
Proper timing of the drug is important; it should be taken starting on about the fifth day of the cycle, and there should be frequent intercourse.
The following procedures may be used to monitor induced cycles:
Follicular monitoring with vaginal ultrasound, starting 4–6 days after last pill. Serial transvaginal ultrasound can reveal the size and number of developing follicles. It can also provide presumptive evidence of ovulation such as sudden collapse of the preovulatory follicle, and an increase in fluid volume in the rectouterine pouch. After ovulation, it may reveal signs of luteinization such as loss of clearly defined follicular margins and appearance of internal echoes.
Serum estradiol levels, starting 4–6 days after last pill
Post-coital test 1–3 days before ovulation to check whether there are at least 5 progressive sperm per HPF
Adequacy of LH surge by urine LH surge tests 3 to 4 days after last clomifene pill
Mid-luteal progesterone, with at least 10 ng/ml 7–9 days after ovulation being regarded as adequate.
Repeat dosing: This 5-day treatment course can be repeated every 30 days. The dosage may be increased by 50-mg increments in subsequent cycles until ovulation is achieved.It is not recommended by the manufacturer to use clomifene for more than 6 cycles.
It is no longer recommended to perform an ultrasound examination to exclude any significant residual ovarian enlargement before each new treatment cycle.
Clomifene is sometimes used in the treatment of male hypogonadism as an alternative to testosterone replacement therapy.It has been found to increase testosterone levels by 2- to 2.5-fold in hypogonadal men.
How clomiphene works?
The chemical structure of clomiphene is very similar to estrogen. When clomiphene is taken, the drug fills up all the estrogen receptors on the pituitary gland, and "fools" the brain into thinking that the estrogen level in the blood is very low. The pituitary gland then responds to this low estrogen signal by secreting extra amounts of the hormones LH and FSH. LH (luteinizing hormone) and FSH (follicle stimulating hormone) are the two hormones that stimulate the ovary to produce eggs.
Before taking clomifene:
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking clomifene it is important that your doctor knows:
If you think you may already be pregnant.
If you have liver problems.
If you have been told you have ovarian cysts or uterine fibroids.
If you have been told you have a hormone-dependent tumour (this is a cancer which is made worse by hormones).
If you have heavy or unusual menstrual periods.
If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
If you have ever had an allergic reaction to a medicine.
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