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|Storage:||Shading, Confined Preservation||Assay(by HPLC)::||98.0-101.2%min|
Estrogen Blocker Steroids,
Pharma Grade Steroids
Pharmaceutical Antiandrogen Drug Exemestane Aromasin Powder CAS 107868-30-4
Exemestane(trade name Aromasin) is a steroidal inhibitor of aromatase which effectively blocks estrogen synthesis in postmenopausal women. It is used as therapy of estrogen receptor positive breast cancer, usually after resection and after failure of tamoxifen. Some breast cancers require estrogen to grow. Those cancers have estrogen receptors (ERs), and are called ER-positive. They may also be called estrogen-responsive, hormonally-responsive, or hormone-receptor-positive. Aromatase is an enzyme that synthesizes estrogen. Aromatase inhibitors block the synthesis of estrogen. This lowers the estrogen level, and slows the growth of cancers.
Exemestane is usually not used in women of childbearing age.
Product Category: Pharmaceutical raw materials and intermediates
CAS Number: 107868-30-4
Molecular formula: C20H24O2
Packing specifications: 25kg / barrel
Appearance: white to slightly yellow crystalline powder
Grade : Pharmaceutical Grade
Storage: Shading, confined preservation
Assay(by HPLC): 98.0-101.2%min
Usage: Developed to help fight breast cancer, Aromasin is one of the most powerful estrogen suppressing compounds
|Description||White Crystalline Powder||White Powder|
|Loss On Drying||0.5%max||0.19%|
|Specific Rotation||+288°~ +298°||+290.2°|
|Residue On Ignition||0.1%max||0.03%|
|Heavy Metals||20PPm max||<10PPm|
How Exemestane Works:
Many breast cancers are stimulated to grow by the female sex hormones oestrogen and progesterone. These breast cancers are called hormone sensitive or hormone receptor positive and can be treated with drugs that block the effects of these hormones.
In women who have had their menopause, oestrogen is mainly produced by changing androgens (sex hormones produced by the adrenal glands) into oestrogens. This process is called aromatisation and happens mainly in the fatty tissues, muscle and the skin. It needs a particular enzyme called aromatase.
Exemestane blocks the process of aromatisation. So it lowers the amount of oestrogen in the body. In early breast cancer, taking exemestane can help to stop breast cancer coming back. In advanced breast cancer the cancer cells may grow more slowly or stop growing completely.
Warnings and Precautions for Using Aromasin:
Aromasin should not be administered to women with pre-menopausal endocrine status. Therefore, whenever clinically appropriate, the post-menopausal status should be ascertained by assessment of LH, FSH and oestradiol levels.
Aromasin should be used with caution in patients with hepatic or renal impairment.
Aromasin tablets contain sucrose and should not be administered to patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency.
Aromasin tablets contain methyl-p-hydroxybenzoate which may cause allergic reactions (possibly delayed).
Aromasin is a potent oestrogen lowering agent, and a reduction in bone mineral density (BMD) and an increased fracture rate have been observed following administration (see section 5.1). At the commencement of adjuvant treatment with Aromasin, women with osteoporosis or at risk of osteoporosis should have treatment baseline bone mineral health assessment based on current clinical guidelines and practice. Patients with advanced disease should have their bone mineral density assessed on a case-by-case basis. Although adequate data to show the effects of therapy in the treatment of the bone mineral density loss caused by Aromasin are not available, patients treated with Aromasin should be carefully monitored and treatment for, or prophylaxis of, osteoporosis should be initiated in at risk patients.
Routine assessment of 25 hydroxy vitamin D levels prior to the start of aromatase inhibitor treatment should be considered, due to the high prevalence of severe deficiency in women with early breast cancer. Women with Vitamin D deficiency should receive supplementation with Vitamin D.
How to Take Exemestane:
Exemestane comes as a tablet to take by mouth. It should be taken once a day after a meal. Take exemestane at around the same time every day. If you miss a dose and it has been less than 12 hours since your regular dose time, take it as soon as you remember. If it is close to your next dose, skip the dose. Do not take 2 doses at once to make up for a missed dose.
Do not take your medication with a high fat meal, as this can increase the medication levels in your blood. The blood levels of this medication can also be affected by certain medications. These include: medications with estrogen including birth control pills or patches and hormone replacement therapy, rifampin, carbamazepine, phenobarbital, phenytoin and St. John’s wort. Be sure to tell your healthcare provider about all medications and supplements you take.
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