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|Boiling Point:||288.125°C At 760 MmHg||Flash Point:||128.054°C|
|Usage 1:||Control Appetite||Usage 2:||Loss Weight|
Fat Loss Steroids,
Weight Loss Steroids
Control Appetite Lose Weight Steroids Burn Fat Lorcaserin Belviq CAS 616202-92-7
Lorcaserin is used with a doctor-approved exercise, behavior change, and reduced-calorie diet program to help you lose weight. It is used by certain overweight people, such as those who are obese or have weight-related medical problems. Losing weightand keeping it off can lessen the many health risks that come with obesity, includingheart disease, diabetes, high blood pressure, and a shorter life. Lorcaserin belongs to a class of drugs known as serotonin receptor agonists. It is thought to work by affecting a certain part of the brain that helps control your appetite.
1. Quick Details:
|Synonym :||Belviq, Apd 356, (1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine|
|Assay :||99% min|
|Boiling point:||288.125°C at 760 mmHg|
|Appearance :||White to almost white crystalline powder|
2. Description of Lorcaserin:
Lorcaserin, currently marketed under the trade name Belviq and previously Lorqess during development, is a weight-loss drug developed by Arena Pharmaceuticals. It has serotonergic properties and acts as an anorectic.
Lorcaserin is used long term for weight loss in those who are obese.
Lorcaserin is a selective 5-HT2C receptor agonist, and in vitro testing of the drug showed reasonable selectivity for 5-HT2C over other related targets.5-HT2C receptors are located almost exclusively in the brain, and can be found in the choroid plexus, cortex, hippocampus, cerebellum, amygdala, thalamus, and hypothalamus. The activation of 5-HT2C receptors in the hypothalamus is supposed to activateproopiomelanocortin (POMC) production and consequently promote weight loss through satiety.This hypothesis is supported by clinical trials and other studies. While it is generally thought that 5-HT2Creceptors help to regulate appetite as well as mood, and endocrine secretion,the exact mechanism of appetite regulation is not yet known. Lorcaserin has shown 100x selectivity for 5-HT2C versus the closely related 5-HT2B receptor, and 17x selectivity over the 5-HT2A receptor.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
A product that may interact with this drug is: cabergoline.
This medication can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include dextromethorphan, among others.
4. Dosage of Lorcaserin :
Lorcaserin is indicated as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in obese adults (a BMI of 30 kg/m2 or greater) or in overweight patients (BMI of 27 kg/m2 or greater) with at least one weight-related comorbid condition, such as hypertension, type-2 diabetes, or dyslipidemia.
The recommended dose is 10 mg orally twice daily with or without food. If patients do not achieve a 5% reduction in weight by week 12, they should stop taking lorcaserin because it is unlikely that they will achieve any weight loss with the medication.
Lorcaserin may be used in patients with mild-to-moderate hepatic impairment who require no dose adjustments; however, caution is recommended for patients with severe hepatic impairment, because the effects in this population have not been studied.Although lorcaserin may be used in patients with mild renal impairment, caution is advised for those with moderate renal impairment. The use of lorcaserin in patients with severe renal impairment or end-stage renal failure is not recommended.
Lorcaserin is contraindicated in pregnant women, and it is listed as a Pregnancy Category X medication. It was found to offer no known benefit in pregnant women, because it promotes weight loss.There are no data supporting the use of the medication in nursing mothers.
|Description||White to kind of white powder||kind of white powder|
|Solubility||Soluble in methanol||Complies|
|Residue on ignition||<0.1%||0.03%|
|Conclusion||Up to the Standard USP 32.|
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