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|CAS Registry Number:||120511-73-1||MF::||C20H24O2|
|Molecular Weight::||296.40||Appearance:||Off-white Crystalline Powder|
|Purity:||99%||Shipping Method:||Air&Sea Transporation,Express|
Estrogen Blocker Steroids,
Pharma Grade Steroids
99% Purity USP Anti Estrogen Steroids , Powder Exemestan Aromasin CAS 107868-30-4
Exemestane is known as a hormonal breast cancer treatment.Exemestane decreases the amount of estrogen the body makes and helps to slow or reverse the growth of these breast cancers.This medication is used to treat certain types of breast cancer (such as hormone-receptor-positive breast cancer) in women after menopause. Exemestane is also used to help prevent the cancer from returning. Some breast cancers are made to grow faster by a natural hormone called estrogen.
1.Exemestan Quick Details
Chemical Name: 6-Methylenandrosta-1,4-diene-3,17-dione
Molecular Weight: 296.40
Appearance: White to almost white powder
Assay: 99.5% min
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Exemestane is known as a hormonal breast cancer treatment.
Some breast cancers need the hormone oestrogen to grow. In women who have been through the menopause, the main source of oestrogen is through the change of sex hormones called androgens into oestrogen. An enzyme called 'aromatase' is needed for this change to occur. Exemestane works by inhibiting (or blocking) this enzyme. This reduces the amount of oestrogen in your body, which slows the growth of the cancer cells.
3.Fuction of Exemestane
1) Exemestane for breast cancer prevention:
Chemoprevention of breast cancer is an effective strategy to reduce the incidence of this disease in women at risk. The first agents to show a significant chemopreventive effect were the SERMs tamoxifen and raloxifen. An updated comprehensive analysis of all SERM prevention trials showed that they are able to reduce the incidence of breast cancer in high- and average-risk women, an effect that is sustained by a reduction in ER-positive invasive breast cancer
2) Exemestane is a third-generation irreversible steroidal inactivator of the aromatase enzyme and is effective in all the treatment settings for breast cancer, including chemoprevention.
In the metastatic setting, exemestane has been extensively investigated as the first-line, second-line, and further-line treatment and is now registered for the treatment of postmenopausal women with advanced hormone-receptor-positive breast cancer whose disease has progressed following antiestrogen therapy. Of note, the potential lack of cross-resistance with NSAIs yields additional opportunities in the treatment sequence of endocrine agents. Furthermore, based on clinically meaningful results, exemestane with everolimus represents an effective therapeutic option for a disease that has progressed after exposure to NSAIs.
Exemestane is generally well tolerated, with a side effect profile similar to that of other AIs and including menopausal symptoms, arthralgia, bone loss, and altered lipid metabolism.
4.How to Take Exemestane
Before you start this treatment, read the manufacturer's printed information leaflet from inside your pack. The manufacturer's leaflet will give you more information about exemestane and a full list of the side-effects which you may experience from taking it.
Take one 25 mg tablet of exemestane each day, exactly as your doctor tells you to. Your dose will be printed on the label of the tablet pack to remind you.
Swallow the tablet with a drink of water, straight after a meal.
You may take exemestane with whichever meal of the day you find easiest to remember, but try to take your doses with the same meal each day. This will help you to avoid missing any doses.
If you forget to take a dose at your usual time, take it as soon as you remember. If you do not remember until the following day, skip the missed dose. Do not take two doses together to make up for a forgotten dose.
Continue to take the tablets regularly each day until your doctor tells you otherwise. You may need to take exemestane for a number of years.
This is dependent on the individual and, also, the amount of aromatizing compounds the person is running. Generally, a good starting dose is 12.5mg ED (every day) or 25mg EOD (every other day). The user must utilize blood work to see how their body is reacting at the starting dosage they choose and then adjust as needed. Experienced anabolic steroid users will usually find a dose they like and stick to it with no problems. As I said already, if you start noticing joint issues then the dose should be lowered; on the other hand, if you start noticing any estrogen related sides, such as puffy or sensitive breasts or water retention, it's time to increase the dosage.
According to literature, the half life is 25-27 hours, which means you can easily get away with taking this drug every other day or once a day.
|Description||White Crystalline Powder||White Powder|
|Loss On Drying||0.5%max||0.19%|
|Specific Rotation||+288°~ +298°||+290.2°|
|Residue On Ignition||0.1%max||0.03%|
|Heavy Metals||20PPm max||<10PPm|
|Conclusion||The specification conform with USP35|
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